DNA damage checkpoints update: Getting molecular

Research output: Contribution to journalArticlepeer-review

174 Scopus citations

Abstract

Eukaryotic checkpoint controls impose delays in the cell cycle in response to DNA damage or defects in DNA replication. Genetic and physiological studies in budding yeast have identified key genes and defined genetic pathways involved in checkpoint-mediated responses. Recent studies now lead to biochemical models that explain at least in part the arrest in G1 and delays during DNA replication after damage. Though progress in checkpoint controls has indeed been rapid, several observations identify puzzling aspects of checkpoint controls with few plausible explanations.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume8
Issue number2
DOIs
StatePublished - Apr 1998

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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