@article{17842807a2964f27a1ed29e4be1fa561,
title = "DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells",
abstract = "Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch. ",
author = "King, {Jessica J.} and Irving, {Kelly L.} and Evans, {Cameron W.} and Chikhale, {Rupesh V.} and Rouven Becker and Morris, {Christopher J.} and {Pe{\~n}a Martinez}, {Cristian D.} and Peter Schofield and Daniel Christ and Hurley, {Laurence H.} and Waller, {Zo{\"e} A.E.} and Iyer, {K. Swaminathan} and Smith, {Nicole M.}",
note = "Funding Information: This work was funded by the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) of Australia, the Cancer Council of Western Australia, and the National Breast Cancer Foundation. R.V.C. was funded by Diabetes UK (18/0005820). Funding Information: The authors thank S. Balasubramanian for his gift of pSANG10-3F-BG4. The authors acknowledge the facilities and technical assistance of the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy, Characterization & Analysis and The University of Western Australia, a facility funded by the University, State and Commonwealth Governments.",
year = "2020",
month = dec,
day = "9",
doi = "10.1021/jacs.0c11708",
language = "English (US)",
volume = "142",
pages = "20600--20604",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "49",
}