DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

Jessica J. King, Kelly L. Irving, Cameron W. Evans, Rupesh V. Chikhale, Rouven Becker, Christopher J. Morris, Cristian D. Peña Martinez, Peter Schofield, Daniel Christ, Laurence H. Hurley, Zoë A.E. Waller, K. Swaminathan Iyer, Nicole M. Smith

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.

Original languageEnglish (US)
Pages (from-to)20600-20604
Number of pages5
JournalJournal of the American Chemical Society
Volume142
Issue number49
DOIs
StatePublished - Dec 9 2020

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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