DNA G-quadruplex and its potential as anticancer drug target

Buket Onel, Clement Lin, Danzhou Yang

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5′ and 3′-untranslated (UTR) regions. The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics. This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres, and the opportunities presented for the development of G-quadruplex-targeted small-molecule drugs.

Original languageEnglish (US)
Pages (from-to)1605-1614
Number of pages10
JournalScience China Chemistry
Volume57
Issue number12
DOIs
StatePublished - Dec 2014

Keywords

  • DNA G-quadruplexes
  • G-quadruplex-targeted small molecules
  • anticancer drug target
  • human telomeres
  • oncogene promoters

ASJC Scopus subject areas

  • Chemistry(all)

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