DNA testing for cancer predisposition.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

PURPOSE/OBJECTIVES: To describe and review scientific and regulatory aspects of molecular genetic technology in the context of DNA testing for cancer predisposition. DATA SOURCES: Published professional articles, texts, and proceedings; commercial testing companies; computerized data bases; and the World Wide Web. DATA SYNTHESIS: This article reviews the basic molecular biology (e.g., DNA, genes, chromosomes, DNA mutations) that is the foundation for indirect and direct methods of DNA testing for cancer predisposition. Key issues in DNA testing include who should be tested, provision of testing, and regulatory concerns. Benefits and problems of testing contribute to its current controversial status. CONCLUSIONS: Understanding the mechanisms of DNA testing for cancer requires knowledge of basic molecular biology. Family history of the cancer in question is a key indicator for predisposition testing. Accessing information regarding research-based testing is challenging. DNA testing for cancer predisposition is not a perfect test, as exemplified by issues related to test regulation and sensitivity. IMPLICATIONS FOR NURSING PRACTICE: Basic knowledge of DNA testing for cancer predisposition will help nurses to (a) have a better understanding of the indications for and ramifications of testing, (b) provide information about testing to patients and the lay public, (c) counsel patients and families at high risk for inherited cancers more effectively, and (d) interpret DNA test results.

Original languageEnglish (US)
Pages (from-to)1317-1327
Number of pages11
JournalOncology Nursing Forum
Volume25
Issue number8
StatePublished - Sep 1998

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DNA
Neoplasms
Molecular Biology
Nursing
Chromosomes
Nurses
Databases
Technology
Mutation
Research
Genes

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

DNA testing for cancer predisposition. / Loescher, Lois J.

In: Oncology Nursing Forum, Vol. 25, No. 8, 09.1998, p. 1317-1327.

Research output: Contribution to journalArticle

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abstract = "PURPOSE/OBJECTIVES: To describe and review scientific and regulatory aspects of molecular genetic technology in the context of DNA testing for cancer predisposition. DATA SOURCES: Published professional articles, texts, and proceedings; commercial testing companies; computerized data bases; and the World Wide Web. DATA SYNTHESIS: This article reviews the basic molecular biology (e.g., DNA, genes, chromosomes, DNA mutations) that is the foundation for indirect and direct methods of DNA testing for cancer predisposition. Key issues in DNA testing include who should be tested, provision of testing, and regulatory concerns. Benefits and problems of testing contribute to its current controversial status. CONCLUSIONS: Understanding the mechanisms of DNA testing for cancer requires knowledge of basic molecular biology. Family history of the cancer in question is a key indicator for predisposition testing. Accessing information regarding research-based testing is challenging. DNA testing for cancer predisposition is not a perfect test, as exemplified by issues related to test regulation and sensitivity. IMPLICATIONS FOR NURSING PRACTICE: Basic knowledge of DNA testing for cancer predisposition will help nurses to (a) have a better understanding of the indications for and ramifications of testing, (b) provide information about testing to patients and the lay public, (c) counsel patients and families at high risk for inherited cancers more effectively, and (d) interpret DNA test results.",
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