Abstract
The present study and model systems were designed to determine whether anesthetics and gases directly affect electron mobility and excitation in a corona discharge induced by field strengths comparable to electric fields that occur within neuronal membranes. The marked inhibition of electron mobility by potent anesthetics we observed suggests that hydrophobic solubility determines the anesthetic presence at the site of action, and alteration of electron mobility may determine anesthetic effect therein by preventing dipole related protein conformational response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 936-940 |
| Number of pages | 5 |
| Journal | Anesthesia and Analgesia |
| Volume | 62 |
| Issue number | 10 |
| State | Published - 1983 |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Do anesthetics act by altering electron mobility? / Hameroff, Stuart R; Watt, R. C.
In: Anesthesia and Analgesia, Vol. 62, No. 10, 1983, p. 936-940.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Do anesthetics act by altering electron mobility?
AU - Hameroff, Stuart R
AU - Watt, R. C.
PY - 1983
Y1 - 1983
N2 - The present study and model systems were designed to determine whether anesthetics and gases directly affect electron mobility and excitation in a corona discharge induced by field strengths comparable to electric fields that occur within neuronal membranes. The marked inhibition of electron mobility by potent anesthetics we observed suggests that hydrophobic solubility determines the anesthetic presence at the site of action, and alteration of electron mobility may determine anesthetic effect therein by preventing dipole related protein conformational response.
AB - The present study and model systems were designed to determine whether anesthetics and gases directly affect electron mobility and excitation in a corona discharge induced by field strengths comparable to electric fields that occur within neuronal membranes. The marked inhibition of electron mobility by potent anesthetics we observed suggests that hydrophobic solubility determines the anesthetic presence at the site of action, and alteration of electron mobility may determine anesthetic effect therein by preventing dipole related protein conformational response.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020955753&partnerID=8YFLogxK
M3 - Article
C2 - 6614526
AN - SCOPUS:0020955753
VL - 62
SP - 936
EP - 940
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 10
ER -