Do patients with HIV-associated minor cognitive/motor disorder exhibit a “subcortical” memory profile? evidence using the california verbal learning test

Dean C. Delis, Guerry Peavy, Robert Heaton, Nelson Butters, David P. Salmon, Michael Taylor, Julie Stout, Parag Mehta, T Lee Ryan, Desiree White, J. Hampton Atkinson, James L. Chandler, J. Allen McCutchan, Igor Grant, Hnrc Group

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A new diagnostic category for HIV seropositive patients–Minor Cognitive/Motor Disorder (MCMD)—was recently proposed by an AIDS task force sponsored by the American Academy of Neurology. Based on past memory research with HIV+ patients who were diagnosed according to the Center for Disease Control (CDC) definition of AIDS, we predicted that HIV+ patients who met the new criteria for MCMD would exhibit a “subcortical” memory profile (i.e., they would display primarily a retrieval deficit). This hypothesis was generally supported, but with some exceptions. The HIV+ patients with MCMD were found to have a mild encoding deficit (suggestive of some cortical involvement) superimposed on a pronounced retrieval deficit (suggestive of more extensive subcortical involvement). These findings are consonant with those from a recent neuropathological study indicating an increase in cortical involvement, in addition to predominately subcortical involvement, in more advance stages of the HIV disease process.

Original languageEnglish (US)
Pages (from-to)151-165
Number of pages15
JournalAssessment
Volume2
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Psychology
  • Applied Psychology

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    Delis, D. C., Peavy, G., Heaton, R., Butters, N., Salmon, D. P., Taylor, M., Stout, J., Mehta, P., Ryan, T. L., White, D., Atkinson, J. H., Chandler, J. L., McCutchan, J. A., Grant, I., & Group, H. (1995). Do patients with HIV-associated minor cognitive/motor disorder exhibit a “subcortical” memory profile? evidence using the california verbal learning test. Assessment, 2(2), 151-165. https://doi.org/10.1177/107319119500200205