Do telomeres ask checkpoint proteins: "Gimme Shelter-in"?

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Telomeres are complicated structures designed to allow one thing and avoid another. They allow replication of chromosome ends, an issue mostly about telomerase, which we seem to understand (though details of its regulation are works in progress). Telomeres must also avoid being detected as DNA breaks. This is important for two reasons: DNA breaks activate checkpoints that cause arrest of cell division, and DNA breaks engage repair machinery. Clearly, normal telomeres neither activate cell cycle arrest nor allow themselves to be repaired; arrest blocks cell division, and repair fuses chromosomes.

Original languageEnglish (US)
Pages (from-to)725-726
Number of pages2
JournalDevelopmental Cell
Volume9
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

DNA Breaks
Telomere
Cells
Chromosomes
Cell Division
DNA
Repair
Proteins
Telomerase
Electric fuses
Cell Cycle Checkpoints
Machinery

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Do telomeres ask checkpoint proteins : "Gimme Shelter-in"? / Weinert, Ted.

In: Developmental Cell, Vol. 9, No. 6, 12.2005, p. 725-726.

Research output: Contribution to journalArticle

@article{905419e6c62a447e8d11c7c9d82d6452,
title = "Do telomeres ask checkpoint proteins: {"}Gimme Shelter-in{"}?",
abstract = "Telomeres are complicated structures designed to allow one thing and avoid another. They allow replication of chromosome ends, an issue mostly about telomerase, which we seem to understand (though details of its regulation are works in progress). Telomeres must also avoid being detected as DNA breaks. This is important for two reasons: DNA breaks activate checkpoints that cause arrest of cell division, and DNA breaks engage repair machinery. Clearly, normal telomeres neither activate cell cycle arrest nor allow themselves to be repaired; arrest blocks cell division, and repair fuses chromosomes.",
author = "Ted Weinert",
year = "2005",
month = "12",
doi = "10.1016/j.devcel.2005.11.012",
language = "English (US)",
volume = "9",
pages = "725--726",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Do telomeres ask checkpoint proteins

T2 - "Gimme Shelter-in"?

AU - Weinert, Ted

PY - 2005/12

Y1 - 2005/12

N2 - Telomeres are complicated structures designed to allow one thing and avoid another. They allow replication of chromosome ends, an issue mostly about telomerase, which we seem to understand (though details of its regulation are works in progress). Telomeres must also avoid being detected as DNA breaks. This is important for two reasons: DNA breaks activate checkpoints that cause arrest of cell division, and DNA breaks engage repair machinery. Clearly, normal telomeres neither activate cell cycle arrest nor allow themselves to be repaired; arrest blocks cell division, and repair fuses chromosomes.

AB - Telomeres are complicated structures designed to allow one thing and avoid another. They allow replication of chromosome ends, an issue mostly about telomerase, which we seem to understand (though details of its regulation are works in progress). Telomeres must also avoid being detected as DNA breaks. This is important for two reasons: DNA breaks activate checkpoints that cause arrest of cell division, and DNA breaks engage repair machinery. Clearly, normal telomeres neither activate cell cycle arrest nor allow themselves to be repaired; arrest blocks cell division, and repair fuses chromosomes.

UR - http://www.scopus.com/inward/record.url?scp=28444486372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28444486372&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2005.11.012

DO - 10.1016/j.devcel.2005.11.012

M3 - Article

C2 - 16326384

AN - SCOPUS:28444486372

VL - 9

SP - 725

EP - 726

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 6

ER -