Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review

Kaitlin Graham, Paula F. Moon-Massat, Evan C. Unger

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, whereas anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This minireview summarizes our progress in developing a battlefield-ready product to prevent combat death due to hemorrhagic shock and/or TBI. Preclinical studies, for both indications, show promising effects of DDFPe as a resuscitation fluid. DDFPe may become a part of the toolkit for tactical healthcare professionals in battlefield and domestic emergency medicine.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalShock
Volume52
Issue number1S
DOIs
StatePublished - Oct 1 2019
Externally publishedYes

Fingerprint

Hemorrhagic Shock
Emulsions
Resuscitation
Oxygen
Fluorocarbons
Nanotechnology
Emergency Medicine
Reperfusion Injury
Anti-Inflammatory Agents
Therapeutics
Delivery of Health Care
perfluoropentane
Traumatic Brain Injury

Keywords

  • Hypoxia
  • nanoemulsion
  • oxygen therapeutic
  • perfluorocarbon
  • prehospital resuscitation

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury : A review. / Graham, Kaitlin; Moon-Massat, Paula F.; Unger, Evan C.

In: Shock, Vol. 52, No. 1S, 01.10.2019, p. 50-54.

Research output: Contribution to journalReview article

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