Does prostate volume correlate with Vitamin D deficiency among men undergoing prostate biopsy?

A. B. Murphy, Y. A. Nyame, K. Batai, R. Kalu, A. Khan, P. Gogana, M. Dixon, V. Macias, A. Kajdacsy-Balla, C. M.P. Hollowell, W. J. Catalona, Rick A Kittles

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives:Recent studies demonstrate Vitamin D is inversely correlated with BPH and prostate cancer (PCA) incidence. We aim to clarify the associations of Vitamin D with prostate volume.Methods:This is an observational study investigating the associations of serum PSA, PSA density and prostate volume with serum 25-hydroxyVitamin D (25-OH D) in PCA patients and men with negative biopsies seen in outpatient urology clinics in Chicago, IL, USA. There were 571 men (40-79 years old) with elevated PSA or abnormal digital rectal examination with available prostate volume recorded from initial biopsy. The primary outcomes were the unadjusted associations of serum 25-OH D deficiency with prostate volume. The secondary outcomes were the adjusted associations using linear and logistic regression analysis.Results:On univariate analysis, serum 25-OH D<20 ng ml-1 inversely correlated with prostate volume among all men undergoing transrectal ultrasonography (P=0.02), and this relationship remained significant for men with negative biopsy on stratified analysis. In adjusted models, controlling for age, serum PSA, 5-a reductase inhibitors use, obesity and PCA diagnosis, prostate volume was inversely associated with Vitamin D (P<0.05) using serum Vitamin D as a continuous and categorical variable. Logistic regression model also demonstrated an inverse association between Vitamin D (continuous and categorical) and prostate volume ≥40 grams.Conclusion:Serum 25-OH D levels are inversely associated with overall prostate volume and enlarged prostate gland (≥40 grams), especially in men with benign prostatic disease. Given the largely non-Toxic effect of supplementation, consideration should be given to assessing Vitamin D levels in men with benign prostatic disease in addition, to malignant prostatic disease.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume20
Issue number1
DOIs
StatePublished - Mar 1 2017

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Vitamin D Deficiency
Prostate
Vitamin D
Biopsy
Prostatic Diseases
Serum
Prostatic Neoplasms
Logistic Models
Digital Rectal Examination
Urology
Ambulatory Care Facilities
Observational Studies
Linear Models
Ultrasonography
Oxidoreductases
Obesity
Regression Analysis
Incidence

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Does prostate volume correlate with Vitamin D deficiency among men undergoing prostate biopsy? / Murphy, A. B.; Nyame, Y. A.; Batai, K.; Kalu, R.; Khan, A.; Gogana, P.; Dixon, M.; Macias, V.; Kajdacsy-Balla, A.; Hollowell, C. M.P.; Catalona, W. J.; Kittles, Rick A.

In: Prostate Cancer and Prostatic Diseases, Vol. 20, No. 1, 01.03.2017, p. 55-60.

Research output: Contribution to journalArticle

Murphy, AB, Nyame, YA, Batai, K, Kalu, R, Khan, A, Gogana, P, Dixon, M, Macias, V, Kajdacsy-Balla, A, Hollowell, CMP, Catalona, WJ & Kittles, RA 2017, 'Does prostate volume correlate with Vitamin D deficiency among men undergoing prostate biopsy?', Prostate Cancer and Prostatic Diseases, vol. 20, no. 1, pp. 55-60. https://doi.org/10.1038/pcan.2016.41
Murphy, A. B. ; Nyame, Y. A. ; Batai, K. ; Kalu, R. ; Khan, A. ; Gogana, P. ; Dixon, M. ; Macias, V. ; Kajdacsy-Balla, A. ; Hollowell, C. M.P. ; Catalona, W. J. ; Kittles, Rick A. / Does prostate volume correlate with Vitamin D deficiency among men undergoing prostate biopsy?. In: Prostate Cancer and Prostatic Diseases. 2017 ; Vol. 20, No. 1. pp. 55-60.
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abstract = "Objectives:Recent studies demonstrate Vitamin D is inversely correlated with BPH and prostate cancer (PCA) incidence. We aim to clarify the associations of Vitamin D with prostate volume.Methods:This is an observational study investigating the associations of serum PSA, PSA density and prostate volume with serum 25-hydroxyVitamin D (25-OH D) in PCA patients and men with negative biopsies seen in outpatient urology clinics in Chicago, IL, USA. There were 571 men (40-79 years old) with elevated PSA or abnormal digital rectal examination with available prostate volume recorded from initial biopsy. The primary outcomes were the unadjusted associations of serum 25-OH D deficiency with prostate volume. The secondary outcomes were the adjusted associations using linear and logistic regression analysis.Results:On univariate analysis, serum 25-OH D<20 ng ml-1 inversely correlated with prostate volume among all men undergoing transrectal ultrasonography (P=0.02), and this relationship remained significant for men with negative biopsy on stratified analysis. In adjusted models, controlling for age, serum PSA, 5-a reductase inhibitors use, obesity and PCA diagnosis, prostate volume was inversely associated with Vitamin D (P<0.05) using serum Vitamin D as a continuous and categorical variable. Logistic regression model also demonstrated an inverse association between Vitamin D (continuous and categorical) and prostate volume ≥40 grams.Conclusion:Serum 25-OH D levels are inversely associated with overall prostate volume and enlarged prostate gland (≥40 grams), especially in men with benign prostatic disease. Given the largely non-Toxic effect of supplementation, consideration should be given to assessing Vitamin D levels in men with benign prostatic disease in addition, to malignant prostatic disease.",
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T1 - Does prostate volume correlate with Vitamin D deficiency among men undergoing prostate biopsy?

AU - Murphy, A. B.

AU - Nyame, Y. A.

AU - Batai, K.

AU - Kalu, R.

AU - Khan, A.

AU - Gogana, P.

AU - Dixon, M.

AU - Macias, V.

AU - Kajdacsy-Balla, A.

AU - Hollowell, C. M.P.

AU - Catalona, W. J.

AU - Kittles, Rick A

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objectives:Recent studies demonstrate Vitamin D is inversely correlated with BPH and prostate cancer (PCA) incidence. We aim to clarify the associations of Vitamin D with prostate volume.Methods:This is an observational study investigating the associations of serum PSA, PSA density and prostate volume with serum 25-hydroxyVitamin D (25-OH D) in PCA patients and men with negative biopsies seen in outpatient urology clinics in Chicago, IL, USA. There were 571 men (40-79 years old) with elevated PSA or abnormal digital rectal examination with available prostate volume recorded from initial biopsy. The primary outcomes were the unadjusted associations of serum 25-OH D deficiency with prostate volume. The secondary outcomes were the adjusted associations using linear and logistic regression analysis.Results:On univariate analysis, serum 25-OH D<20 ng ml-1 inversely correlated with prostate volume among all men undergoing transrectal ultrasonography (P=0.02), and this relationship remained significant for men with negative biopsy on stratified analysis. In adjusted models, controlling for age, serum PSA, 5-a reductase inhibitors use, obesity and PCA diagnosis, prostate volume was inversely associated with Vitamin D (P<0.05) using serum Vitamin D as a continuous and categorical variable. Logistic regression model also demonstrated an inverse association between Vitamin D (continuous and categorical) and prostate volume ≥40 grams.Conclusion:Serum 25-OH D levels are inversely associated with overall prostate volume and enlarged prostate gland (≥40 grams), especially in men with benign prostatic disease. Given the largely non-Toxic effect of supplementation, consideration should be given to assessing Vitamin D levels in men with benign prostatic disease in addition, to malignant prostatic disease.

AB - Objectives:Recent studies demonstrate Vitamin D is inversely correlated with BPH and prostate cancer (PCA) incidence. We aim to clarify the associations of Vitamin D with prostate volume.Methods:This is an observational study investigating the associations of serum PSA, PSA density and prostate volume with serum 25-hydroxyVitamin D (25-OH D) in PCA patients and men with negative biopsies seen in outpatient urology clinics in Chicago, IL, USA. There were 571 men (40-79 years old) with elevated PSA or abnormal digital rectal examination with available prostate volume recorded from initial biopsy. The primary outcomes were the unadjusted associations of serum 25-OH D deficiency with prostate volume. The secondary outcomes were the adjusted associations using linear and logistic regression analysis.Results:On univariate analysis, serum 25-OH D<20 ng ml-1 inversely correlated with prostate volume among all men undergoing transrectal ultrasonography (P=0.02), and this relationship remained significant for men with negative biopsy on stratified analysis. In adjusted models, controlling for age, serum PSA, 5-a reductase inhibitors use, obesity and PCA diagnosis, prostate volume was inversely associated with Vitamin D (P<0.05) using serum Vitamin D as a continuous and categorical variable. Logistic regression model also demonstrated an inverse association between Vitamin D (continuous and categorical) and prostate volume ≥40 grams.Conclusion:Serum 25-OH D levels are inversely associated with overall prostate volume and enlarged prostate gland (≥40 grams), especially in men with benign prostatic disease. Given the largely non-Toxic effect of supplementation, consideration should be given to assessing Vitamin D levels in men with benign prostatic disease in addition, to malignant prostatic disease.

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DO - 10.1038/pcan.2016.41

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VL - 20

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JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

SN - 1365-7852

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