Donors of HNO

Katrina M. Miranda, Herbert T. Nagasawa, John P. Toscano

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.

Original languageEnglish (US)
Pages (from-to)649-664
Number of pages16
JournalCurrent topics in medicinal chemistry
Volume5
Issue number7
DOIs
StatePublished - Aug 31 2005

Keywords

  • Acyl nitroso compounds
  • Angeli's salt
  • Characterization
  • Cyanamide
  • Detection
  • Hydroxylamines
  • Nitric oxide
  • Nitroxyl
  • Piloty's acid
  • Prodrugs
  • Sulfohydroxamic acids

ASJC Scopus subject areas

  • Drug Discovery

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