Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum

Martin H. Teicher, Amelia L. Gallitano, Harris A. Gelbard, Henriette K. Evans, Elda R. Marsh, Raymond G. Booth, Ross J. Baldessarini

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Synthesis-modulating dopamine (DA) autoreceptor function was studied in vivo using γ-butyrolactone (GBL) to block propagation along DA axons. DA synthesis was measured by the accumulation of l-3,4-dihydroxyphenylalanine (l-DOPA) after inhibition of aromatic l-amino acid decarboxylase. GBL treatment markedly increased DOPA accumulation in both the striatum and prefrontal cortex of developing rats. The selective DA partial D1 agonist SKF-38393 inhibited this GBL-induced rise in DA synthesis in both the striatum and prefrontal cortex of 15- and 22-day-old rats, but not in adults. The effects of SKF-38393 in developing rats were mimicked by the non-catechol D1 partial agonist CY-208-243, and were blocked by the D1 antagonist SCH-23390, suggesting receptor mediation. The mixed D2/D3 agonist quinpirole attenuated DA synthesis in striatum of both two-week-old and adult rats, but failed to inhibit the GBL-induced increase in DA synthesis in the developing prefrontal cortex. These findings suggest that synthesis-modulating D1-like receptor function may emerge transiently in the developing mammalian forebrain. In the adult striatum these functions appear to be subsumed by D2-like receptors, whereas all synthesis-modulating DA receptor function in prefrontal cortex appears to be essentially lost with maturation.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalDevelopmental Brain Research
Volume63
Issue number1-2
DOIs
StatePublished - Nov 19 1991
Externally publishedYes

Keywords

  • Autoreceptor
  • Corpus striatum
  • Dopamine
  • Dopamine agonist
  • Dopamine receptor
  • Prefrontal cortex
  • Presynaptic receptor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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