Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum

Martin H. Teicher, Amelia L Gallitano-Mendel, Harris A. Gelbard, Henriette K. Evans, Elda R. Marsh, Raymond G. Booth, Ross J. Baldessarini

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Synthesis-modulating dopamine (DA) autoreceptor function was studied in vivo using γ-butyrolactone (GBL) to block propagation along DA axons. DA synthesis was measured by the accumulation of l-3,4-dihydroxyphenylalanine (l-DOPA) after inhibition of aromatic l-amino acid decarboxylase. GBL treatment markedly increased DOPA accumulation in both the striatum and prefrontal cortex of developing rats. The selective DA partial D1 agonist SKF-38393 inhibited this GBL-induced rise in DA synthesis in both the striatum and prefrontal cortex of 15- and 22-day-old rats, but not in adults. The effects of SKF-38393 in developing rats were mimicked by the non-catechol D1 partial agonist CY-208-243, and were blocked by the D1 antagonist SCH-23390, suggesting receptor mediation. The mixed D2/D3 agonist quinpirole attenuated DA synthesis in striatum of both two-week-old and adult rats, but failed to inhibit the GBL-induced increase in DA synthesis in the developing prefrontal cortex. These findings suggest that synthesis-modulating D1-like receptor function may emerge transiently in the developing mammalian forebrain. In the adult striatum these functions appear to be subsumed by D2-like receptors, whereas all synthesis-modulating DA receptor function in prefrontal cortex appears to be essentially lost with maturation.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalDevelopmental Brain Research
Volume63
Issue number1-2
DOIs
StatePublished - Nov 19 1991
Externally publishedYes

Fingerprint

Autoreceptors
Prefrontal Cortex
Dopamine
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Aromatic-L-Amino-Acid Decarboxylases
Quinpirole
Dihydroxyphenylalanine
Dopamine Receptors
Prosencephalon
Axons

Keywords

  • Autoreceptor
  • Corpus striatum
  • Dopamine
  • Dopamine agonist
  • Dopamine receptor
  • Prefrontal cortex
  • Presynaptic receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Dopamine D1 autoreceptor function : possible expression in developing rat prefrontal cortex and striatum. / Teicher, Martin H.; Gallitano-Mendel, Amelia L; Gelbard, Harris A.; Evans, Henriette K.; Marsh, Elda R.; Booth, Raymond G.; Baldessarini, Ross J.

In: Developmental Brain Research, Vol. 63, No. 1-2, 19.11.1991, p. 229-235.

Research output: Contribution to journalArticle

Teicher, Martin H. ; Gallitano-Mendel, Amelia L ; Gelbard, Harris A. ; Evans, Henriette K. ; Marsh, Elda R. ; Booth, Raymond G. ; Baldessarini, Ross J. / Dopamine D1 autoreceptor function : possible expression in developing rat prefrontal cortex and striatum. In: Developmental Brain Research. 1991 ; Vol. 63, No. 1-2. pp. 229-235.
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