Dopamine D1 receptor development depends on endogenous dopamine

Harris A. Gelbard, Martin H. Teicher, Ross J. Baldessarini, Amelia L Gallitano-Mendel, Elda R. Marsh, Joseph Zorc, Gianni Faedda

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Profound depletion of forebrain dopamine by 6-hydroxydopamine in neonatal rats (day 3) was associated with up to 82% loss of D1 receptor sites labeled with [3H]SCH-23390 at day 21. Administration of the selective D1 agonist SKF-38393 (days 6-18) abolished the correlation between D1 receptor density and DA concentrations, even with >99% depletion of DA. In intact control animals, there was an inverse correlation between spontaneous variation in levels of DA and D1 receptor site density in forebrain tissue (r = -0.79) which also was abolished by treatment with the D1 agonist. Thus, D1 receptor density may be regulated by reciprocal regulatory processes during normal development, but may fail to develop in the absence of an adequate level of stimulation.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalDevelopmental Brain Research
Volume56
Issue number1
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

Fingerprint

Dopamine D1 Receptors
Prosencephalon
Dopamine
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Oxidopamine
SCH 23390

Keywords

  • 6-Hydroxydopamine
  • Development
  • Dopamine
  • Dopamine D receptor
  • Limbic system
  • Striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Gelbard, H. A., Teicher, M. H., Baldessarini, R. J., Gallitano-Mendel, A. L., Marsh, E. R., Zorc, J., & Faedda, G. (1990). Dopamine D1 receptor development depends on endogenous dopamine. Developmental Brain Research, 56(1), 137-140. https://doi.org/10.1016/0165-3806(90)90173-V

Dopamine D1 receptor development depends on endogenous dopamine. / Gelbard, Harris A.; Teicher, Martin H.; Baldessarini, Ross J.; Gallitano-Mendel, Amelia L; Marsh, Elda R.; Zorc, Joseph; Faedda, Gianni.

In: Developmental Brain Research, Vol. 56, No. 1, 01.10.1990, p. 137-140.

Research output: Contribution to journalArticle

Gelbard, HA, Teicher, MH, Baldessarini, RJ, Gallitano-Mendel, AL, Marsh, ER, Zorc, J & Faedda, G 1990, 'Dopamine D1 receptor development depends on endogenous dopamine', Developmental Brain Research, vol. 56, no. 1, pp. 137-140. https://doi.org/10.1016/0165-3806(90)90173-V
Gelbard, Harris A. ; Teicher, Martin H. ; Baldessarini, Ross J. ; Gallitano-Mendel, Amelia L ; Marsh, Elda R. ; Zorc, Joseph ; Faedda, Gianni. / Dopamine D1 receptor development depends on endogenous dopamine. In: Developmental Brain Research. 1990 ; Vol. 56, No. 1. pp. 137-140.
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