Dopamine D1 receptor development depends on endogenous dopamine

Harris A. Gelbard, Martin H. Teicher, Ross J. Baldessarini, Amelia Gallitano, Elda R. Marsh, Joseph Zorc, Gianni Faedda

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Profound depletion of forebrain dopamine by 6-hydroxydopamine in neonatal rats (day 3) was associated with up to 82% loss of D1 receptor sites labeled with [3H]SCH-23390 at day 21. Administration of the selective D1 agonist SKF-38393 (days 6-18) abolished the correlation between D1 receptor density and DA concentrations, even with >99% depletion of DA. In intact control animals, there was an inverse correlation between spontaneous variation in levels of DA and D1 receptor site density in forebrain tissue (r = -0.79) which also was abolished by treatment with the D1 agonist. Thus, D1 receptor density may be regulated by reciprocal regulatory processes during normal development, but may fail to develop in the absence of an adequate level of stimulation.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalDevelopmental Brain Research
Volume56
Issue number1
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

Keywords

  • 6-Hydroxydopamine
  • Development
  • Dopamine
  • Dopamine D receptor
  • Limbic system
  • Striatum

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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    Gelbard, H. A., Teicher, M. H., Baldessarini, R. J., Gallitano, A., Marsh, E. R., Zorc, J., & Faedda, G. (1990). Dopamine D1 receptor development depends on endogenous dopamine. Developmental Brain Research, 56(1), 137-140. https://doi.org/10.1016/0165-3806(90)90173-V