Dopamine modulation of prefrontal delay activity-reverberatory activity and sharpness of tuning curves

Gabriele Scheler, Jean-Marc Fellous

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent electrophysiological experiments have shown that dopamine (D1) modulation of pyramidal cells in prefrontal cortex reduces spike frequency adaptation and enhances NMDA transmission. Using four models, from multicompartmental to integrate-and-fire, we examine the effects of these modulations on sustained (delay) activity in a reverberatory network. We find that D1 modulation may enable robust network bistability yielding selective reverberation among cells that code for a particular item or location. We further show that the tuning curve of such cells is sharpened, and that signal-to-noise ratio is increased. We postulate that D1 modulation affects the tuning of "memory fields" and yield efficient distributed dynamic representations.

Original languageEnglish (US)
Pages (from-to)1549-1556
Number of pages8
JournalNeurocomputing
Volume38-40
DOIs
StatePublished - Jun 2001
Externally publishedYes

Fingerprint

Dopamine
Tuning
Modulation
Pyramidal Cells
Signal-To-Noise Ratio
N-Methylaspartate
Prefrontal Cortex
Reverberation
Signal to noise ratio
Fires
Data storage equipment
Experiments

Keywords

  • Computational
  • Memory
  • Neuromodulations

ASJC Scopus subject areas

  • Artificial Intelligence
  • Cellular and Molecular Neuroscience

Cite this

Dopamine modulation of prefrontal delay activity-reverberatory activity and sharpness of tuning curves. / Scheler, Gabriele; Fellous, Jean-Marc.

In: Neurocomputing, Vol. 38-40, 06.2001, p. 1549-1556.

Research output: Contribution to journalArticle

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