Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder

Mark A. Stein, Irwin Waldman, Jeffrey Newcorn, Jeffrey Bishop, Rick A Kittles, Edwin H. Cook

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVES: This study seeks to determine if variation in the dopamine transporter gene (SLC6A3/DAT1) moderates the dose-response effects of long-acting dexmethylphenidate (D-MPH) and mixed amphetamine salts (MAS) in children with attention-deficit/hyperactivity disorder (ADHD).

METHODS: Fifty-six children and adolescents (mean age=11.7±2.2) participated in a double-blind, two period crossover, dose-response study with a randomized placebo week in each 4 week drug period. Each period consisted of sequential week-long exposures to three dose levels (10, 20, 25-30 mg, depending upon weight) of D-MPH or MAS.

RESULTS: Doses of 10-20 mg of either D-MPH or MAS had little to no effect on hyperactivity-impulsivity and total ADHD symptom scores in subjects with the 9/9 genotype; this was in contrast to the dose-response curves of subjects with either the 10/10 or 10/9 genotype.

CONCLUSIONS: ADHD youth with the 9/9 genotype may require higher stimulant doses to achieve adequate symptom control.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalJournal of Child and Adolescent Psychopharmacology
Volume24
Issue number5
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

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Dopamine Plasma Membrane Transport Proteins
Amphetamine
Attention Deficit Disorder with Hyperactivity
Salts
Genotype
Impulsive Behavior
Placebos
Weights and Measures
Pharmaceutical Preparations
Genes
Dexmethylphenidate Hydrochloride

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder. / Stein, Mark A.; Waldman, Irwin; Newcorn, Jeffrey; Bishop, Jeffrey; Kittles, Rick A; Cook, Edwin H.

In: Journal of Child and Adolescent Psychopharmacology, Vol. 24, No. 5, 01.06.2014, p. 238-244.

Research output: Contribution to journalArticle

Stein, Mark A. ; Waldman, Irwin ; Newcorn, Jeffrey ; Bishop, Jeffrey ; Kittles, Rick A ; Cook, Edwin H. / Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder. In: Journal of Child and Adolescent Psychopharmacology. 2014 ; Vol. 24, No. 5. pp. 238-244.
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