Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder

Mark A. Stein, Irwin Waldman, Jeffrey Newcorn, Jeffrey Bishop, Rick Kittles, Edwin H. Cook

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

OBJECTIVES: This study seeks to determine if variation in the dopamine transporter gene (SLC6A3/DAT1) moderates the dose-response effects of long-acting dexmethylphenidate (D-MPH) and mixed amphetamine salts (MAS) in children with attention-deficit/hyperactivity disorder (ADHD).

METHODS: Fifty-six children and adolescents (mean age=11.7±2.2) participated in a double-blind, two period crossover, dose-response study with a randomized placebo week in each 4 week drug period. Each period consisted of sequential week-long exposures to three dose levels (10, 20, 25-30 mg, depending upon weight) of D-MPH or MAS.

RESULTS: Doses of 10-20 mg of either D-MPH or MAS had little to no effect on hyperactivity-impulsivity and total ADHD symptom scores in subjects with the 9/9 genotype; this was in contrast to the dose-response curves of subjects with either the 10/10 or 10/9 genotype.

CONCLUSIONS: ADHD youth with the 9/9 genotype may require higher stimulant doses to achieve adequate symptom control.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalJournal of child and adolescent psychopharmacology
Volume24
Issue number5
DOIs
StatePublished - Jun 1 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder'. Together they form a unique fingerprint.

Cite this