Doppler Assessment of Diastolic Function Reflect the Severity of Injury in Rats With Chronic Heart Failure

Pablo Sanchez, Jordan J. Lancaster, Kyle Weigand, Saffie Alrahman Ezz Eldin Mohran, Steven Goldman, Elizabeth B Juneman

Research output: Contribution to journalArticle

Abstract

Objective: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF. Myocardial tissue relaxation velocities correlate with traditional measurements of diastolic function (ie, hemodynamics, Tau, and diastolic pressure-volume relationships). Methods and Results: Male Sprague-Dawley rats underwent left coronary artery ligation or sham operation. Echocardiography was performed at 3 and 6 weeks after coronary ligation to evaluate LV ejection fraction (EF) and LV diastolic function through MVI patterns (E, A, and E/A) and Doppler imaging of the anterior wall (e' and a'). The rats were categorized into moderate or severe CHF according to their LV EF at 3 weeks postligation. Invasive hemodynamic measurements with solid-state pressure catheters were obtained at the 6-week endpoint. Moderate (N = 20) and severe CHF (N = 22) rats had significantly (P < .05) different EFs, hemodynamics, and diastolic pressure-volume relationships. Early diastolic anterior wall radial relaxation velocities as well as E/e' ratios separated moderate from severe CHF and both diastolic parameters had strong correlations with invasive hemodynamic measurements of diastolic function. Conclusion: Radial anterior wall e' and E/e' can be used for serial assessment of diastolic function in rats with moderate and severe CHF.

Original languageEnglish (US)
JournalJournal of Cardiac Failure
DOIs
StateAccepted/In press - 2017

Fingerprint

Heart Failure
Hemodynamics
Wounds and Injuries
Mitral Valve
Stroke Volume
Ligation
Diastolic Heart Failure
Blood Pressure
Left Ventricular Function
Sprague Dawley Rats
Echocardiography
Coronary Vessels
Catheters
Pressure

Keywords

  • Diastolic function
  • Echocardiography
  • Heart failure
  • Mitral velocity
  • Rats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Doppler Assessment of Diastolic Function Reflect the Severity of Injury in Rats With Chronic Heart Failure. / Sanchez, Pablo; Lancaster, Jordan J.; Weigand, Kyle; Mohran, Saffie Alrahman Ezz Eldin; Goldman, Steven; Juneman, Elizabeth B.

In: Journal of Cardiac Failure, 2017.

Research output: Contribution to journalArticle

@article{ab2ceab1a6df467d8deec6149c9b0aa9,
title = "Doppler Assessment of Diastolic Function Reflect the Severity of Injury in Rats With Chronic Heart Failure",
abstract = "Objective: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF. Myocardial tissue relaxation velocities correlate with traditional measurements of diastolic function (ie, hemodynamics, Tau, and diastolic pressure-volume relationships). Methods and Results: Male Sprague-Dawley rats underwent left coronary artery ligation or sham operation. Echocardiography was performed at 3 and 6 weeks after coronary ligation to evaluate LV ejection fraction (EF) and LV diastolic function through MVI patterns (E, A, and E/A) and Doppler imaging of the anterior wall (e' and a'). The rats were categorized into moderate or severe CHF according to their LV EF at 3 weeks postligation. Invasive hemodynamic measurements with solid-state pressure catheters were obtained at the 6-week endpoint. Moderate (N = 20) and severe CHF (N = 22) rats had significantly (P < .05) different EFs, hemodynamics, and diastolic pressure-volume relationships. Early diastolic anterior wall radial relaxation velocities as well as E/e' ratios separated moderate from severe CHF and both diastolic parameters had strong correlations with invasive hemodynamic measurements of diastolic function. Conclusion: Radial anterior wall e' and E/e' can be used for serial assessment of diastolic function in rats with moderate and severe CHF.",
keywords = "Diastolic function, Echocardiography, Heart failure, Mitral velocity, Rats",
author = "Pablo Sanchez and Lancaster, {Jordan J.} and Kyle Weigand and Mohran, {Saffie Alrahman Ezz Eldin} and Steven Goldman and Juneman, {Elizabeth B}",
year = "2017",
doi = "10.1016/j.cardfail.2017.08.446",
language = "English (US)",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Doppler Assessment of Diastolic Function Reflect the Severity of Injury in Rats With Chronic Heart Failure

AU - Sanchez, Pablo

AU - Lancaster, Jordan J.

AU - Weigand, Kyle

AU - Mohran, Saffie Alrahman Ezz Eldin

AU - Goldman, Steven

AU - Juneman, Elizabeth B

PY - 2017

Y1 - 2017

N2 - Objective: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF. Myocardial tissue relaxation velocities correlate with traditional measurements of diastolic function (ie, hemodynamics, Tau, and diastolic pressure-volume relationships). Methods and Results: Male Sprague-Dawley rats underwent left coronary artery ligation or sham operation. Echocardiography was performed at 3 and 6 weeks after coronary ligation to evaluate LV ejection fraction (EF) and LV diastolic function through MVI patterns (E, A, and E/A) and Doppler imaging of the anterior wall (e' and a'). The rats were categorized into moderate or severe CHF according to their LV EF at 3 weeks postligation. Invasive hemodynamic measurements with solid-state pressure catheters were obtained at the 6-week endpoint. Moderate (N = 20) and severe CHF (N = 22) rats had significantly (P < .05) different EFs, hemodynamics, and diastolic pressure-volume relationships. Early diastolic anterior wall radial relaxation velocities as well as E/e' ratios separated moderate from severe CHF and both diastolic parameters had strong correlations with invasive hemodynamic measurements of diastolic function. Conclusion: Radial anterior wall e' and E/e' can be used for serial assessment of diastolic function in rats with moderate and severe CHF.

AB - Objective: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF. Myocardial tissue relaxation velocities correlate with traditional measurements of diastolic function (ie, hemodynamics, Tau, and diastolic pressure-volume relationships). Methods and Results: Male Sprague-Dawley rats underwent left coronary artery ligation or sham operation. Echocardiography was performed at 3 and 6 weeks after coronary ligation to evaluate LV ejection fraction (EF) and LV diastolic function through MVI patterns (E, A, and E/A) and Doppler imaging of the anterior wall (e' and a'). The rats were categorized into moderate or severe CHF according to their LV EF at 3 weeks postligation. Invasive hemodynamic measurements with solid-state pressure catheters were obtained at the 6-week endpoint. Moderate (N = 20) and severe CHF (N = 22) rats had significantly (P < .05) different EFs, hemodynamics, and diastolic pressure-volume relationships. Early diastolic anterior wall radial relaxation velocities as well as E/e' ratios separated moderate from severe CHF and both diastolic parameters had strong correlations with invasive hemodynamic measurements of diastolic function. Conclusion: Radial anterior wall e' and E/e' can be used for serial assessment of diastolic function in rats with moderate and severe CHF.

KW - Diastolic function

KW - Echocardiography

KW - Heart failure

KW - Mitral velocity

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=85028705080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028705080&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2017.08.446

DO - 10.1016/j.cardfail.2017.08.446

M3 - Article

C2 - 28801075

AN - SCOPUS:85028705080

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

ER -