Downregulated KV channels and upregulated TRPC channels in primary pulmonary hypertension

Donna D. Tigno, Mehran Mandegar, Carmelle V. Remillard, Jason Yuan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary pulmonary hypertension (PPH) is a progressive, fatal disease of unknown cause. It is characterized by elevation of pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), leading progressively to right heart failure and, eventually, death. Incidence of this disease is rare, occurring in one or two per million in the general population, and predominantly affects women. The time from diagnosis to right heart failure and death is short (median of 2.8 years) (1,2).

Original languageEnglish (US)
Title of host publicationIon Channels in the Pulmonary Vasculature
PublisherCRC Press
Pages543-566
Number of pages24
ISBN (Electronic)9780849350375
ISBN (Print)0824759680, 9780824759681
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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