Drug absorption kinetics in goldfish

Samuel H. Yalkowsky, O. S. Carpenter, Gordon L. Flynn, Thomas G. Slunick

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A model is presented for relating turnover time in goldfish to the concentration of drug in the bathing solution. The model, based on passive transport and the existence of a critical concentration of drug within the fish being required for turnover, was applied to the dose‐response data of eight homologous esters of p‐aminobenzoic acid. Absorption rate constants, relative membrane water partition coefficients, and critical concentrations were evaluated for the methyl through hexyl esters. Heptyl aminobenzoate was only effective in saturated solution. No turnover could be produced by the octyl ester which has a solubility below the critical concentration required for activity.

Original languageEnglish (US)
Pages (from-to)1949-1954
Number of pages6
JournalJournal of pharmaceutical sciences
Volume62
Issue number12
DOIs
StatePublished - Dec 1973
Externally publishedYes

Keywords

  • Dose‐response data—alkyl p‐aminobenzoate‐induced turnover of goldfish
  • Drug absorption kinetics—relationship between turnover time (goldfish) and drug concentration (alkyl p‐aminobenzoates), model, equations
  • Goldfish—drug absorption kinetics, model and equations relating turnover time and alkyl p‐aminobenzoate concentration
  • p‐Aminobenzoic acid esters—model and equations relating drug concentration and goldfish turnover time

ASJC Scopus subject areas

  • Pharmaceutical Science

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