Drug dosing in the critically ill obese patient - A focus on sedation, analgesia, and delirium

Brian L. Erstad, Jeffrey F. Barletta

Research output: Contribution to journalReview article

Abstract

Practice guidelines provide clear evidence-based recommendations for the use of drug therapy to manage pain, agitation, and delirium associated with critical illness. Dosing recommendations however are often based on strategies used in patients with normal body habitus. Recommendations specific to critically ill patients with extreme obesity are lacking. Nonetheless, clinicians must craft dosing regimens for this population. This paper is intended to help clinicians design initial dosing regimens for medications commonly used in the management of pain, agitation, and delirium in critically ill patients with extreme obesity. A detailed literature search was conducted with an emphasis on obesity, pharmacokinetics, and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided.

Original languageEnglish (US)
Article number315
JournalCritical Care
Volume24
Issue number1
DOIs
StatePublished - Jun 8 2020

Keywords

  • Critical illness
  • Drug-dosing
  • Obesity
  • Pharmacokinetics

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Drug dosing in the critically ill obese patient - A focus on sedation, analgesia, and delirium'. Together they form a unique fingerprint.

  • Cite this