Drug exposure and the acquisition and retention of a conditioned taste aversion

Anthony L. Riley, William J Jacobs, Vincent M. LoLordo

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Two experiments, the 1st with 24 female and the 2nd with 18 male Long-Evans rats, examined the effects of pre- and postexposure to a drug on the acquisition and retention of a conditioned taste aversion induced by that drug. Exp I demonstrated that although drug preexposure attenuated a subsequent conditioned aversion, repeated taste-drug pairings reversed the initial attenuation effect and resulted in nearly complete avoidance of consumption. Exp II, however, demonstrated that drug postexposure did not alter a previously established conditioned aversion, although the postexposure experiences were effective in attenuating a conditioned aversion to a 2nd novel solution. It is suggested that conditioned aversions are mediated by ACTH and that preexposure to a drug results in tolerance to that drug, yielding a smaller ACTH response and thereby a weaker aversion. (29 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalJournal of Comparative and Physiological Psychology
Volume90
Issue number8
DOIs
StatePublished - Aug 1976
Externally publishedYes

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Pharmaceutical Preparations
Adrenocorticotropic Hormone
Drug Tolerance
Long Evans Rats

Keywords

  • male rats
  • postexposure to drug, acquisition &
  • pre- &
  • retention of conditioned taste aversion induced by that drug, female &

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Drug exposure and the acquisition and retention of a conditioned taste aversion. / Riley, Anthony L.; Jacobs, William J; LoLordo, Vincent M.

In: Journal of Comparative and Physiological Psychology, Vol. 90, No. 8, 08.1976, p. 799-807.

Research output: Contribution to journalArticle

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