Duplication and deletion of chromosome band 2(p21p22) resulting from a familial interstitial insertion (2;11)(p21;p15)

J. R. Sawyer, E. Jones, F. F. Hawks, J. G. Quirk, C. Cunniff

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Routine amniocentesis for advanced maternal age led to the prenatal diagnosis of a fetus with a karyotype of a 46,XX,del(2)(p21p22). At delivery the baby had holoprosencephaly as the major clinical finding, which has been associated with a deletion of band 2p21 in several other case reports. Chromosome studies of the parents showed a normal 46,XY karyotype in the father, and a balanced interstitial insertion 46,XX dir ins (11;2)(p15.1;p21p22) in the mother. Subsequent chromosome studies of other relatives documented a 23-year-old half-brother of the proposita with a partial trisomy for the segment deleted in the proposita. The half-brother showed the derivative chromosome 11 from the mother, resulting in a 46,XY,der(11)dup(2)(p21p22) karyotype. Major clinical findings include short stature, mild developmental delay, and behavior abnormalities. A half-sister of the proposita is also a balanced carrier of the the dir ins (11;2) (p15.1;p21p22.2). The association of the deletion chromosome band 2p21 and the clinical finding of holoprosencephaly is further supported by the findings in this family.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalAmerican journal of medical genetics
Volume49
Issue number4
DOIs
StatePublished - Jan 1 1994

Keywords

  • holoprosencephaly, deletion 2p21, interstitial insertion

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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