Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate

Samuel A. Jacobs, Nicholas Vidnovic, Hitendra - Patel, Lorinda A. Soma, Yuan Chang, Noah Bass, Steven H. Swerdlow

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Multicentric Castleman disease (MCD) is a nonneoplastic lymphoproliferative disorder that has a poor prognosis. Optimal treatment is unknown. There are a few reported cases of MCD and rheumatoid arthritis. In this study, we report a patient with rheumatoid arthritis diagnosed with Kaposi's sarcoma herpesvirus-(KSHV, human herpesvirus-8) associated MCD that showed expression of viral IL-6. Treatment with methotrexate (MTX) resulted in a complete remission of her disease lasting for 54+ months. Multiple studies have suggested that MCD and rheumatoid arthritis are associated with overexpression of the growth-promoting cytokine interleukin-6 (IL-6), and that MTX downregulates the production of this cytokine in vivo. As such, we suggest that the dramatic improvement in this patient's disease is due to the immunomodulatory properties of MTX.

Original languageEnglish (US)
Pages (from-to)1148-1150
Number of pages3
JournalClinical Rheumatology
Volume26
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Kaposi's Sarcoma
Methotrexate
Rheumatoid Arthritis
HIV
Viruses
Human Herpesvirus 8
Interleukin-6
Cytokines
Lymphoproliferative Disorders
Herpesviridae
Down-Regulation
Multi-centric Castleman's Disease
Therapeutics
Growth

Keywords

  • Castleman disease
  • Interleukin-6
  • Methotrexate

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate. / Jacobs, Samuel A.; Vidnovic, Nicholas; Patel, Hitendra -; Soma, Lorinda A.; Chang, Yuan; Bass, Noah; Swerdlow, Steven H.

In: Clinical Rheumatology, Vol. 26, No. 7, 07.2007, p. 1148-1150.

Research output: Contribution to journalArticle

Jacobs, Samuel A. ; Vidnovic, Nicholas ; Patel, Hitendra - ; Soma, Lorinda A. ; Chang, Yuan ; Bass, Noah ; Swerdlow, Steven H. / Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate. In: Clinical Rheumatology. 2007 ; Vol. 26, No. 7. pp. 1148-1150.
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AB - Multicentric Castleman disease (MCD) is a nonneoplastic lymphoproliferative disorder that has a poor prognosis. Optimal treatment is unknown. There are a few reported cases of MCD and rheumatoid arthritis. In this study, we report a patient with rheumatoid arthritis diagnosed with Kaposi's sarcoma herpesvirus-(KSHV, human herpesvirus-8) associated MCD that showed expression of viral IL-6. Treatment with methotrexate (MTX) resulted in a complete remission of her disease lasting for 54+ months. Multiple studies have suggested that MCD and rheumatoid arthritis are associated with overexpression of the growth-promoting cytokine interleukin-6 (IL-6), and that MTX downregulates the production of this cytokine in vivo. As such, we suggest that the dramatic improvement in this patient's disease is due to the immunomodulatory properties of MTX.

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