Dye leaching from a doped sol-gel is eliminated by conjugation to a dendrimer

Muditha D. Senarath-Yapa, Steven S Saavedra

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The extent of leaching of dye molecules following encapsulation into sol-gel glasses was investigated. Covalent attachment of erythrosin isothiocyanate (EITC) to a polyamidoamine generation 4 (PAMAM) dendrimer, having a molecular weight of 14,215 Da, eliminated all detectable leaching from hydrated monoliths prepared from tetramethylorthosilicate (TMOS). In contrast, a prior study showed that significant leaching takes place when the dye is conjugated to 70 kDa dextran. To eliminate dye leaching via attachment to a macromolecular carrier, an inherently globular macromolecule having an organized secondary structure is therefore required.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalAnalytica Chimica Acta
Volume432
Issue number1
DOIs
StatePublished - Mar 22 2001

Fingerprint

Dendrimers
Polymethyl Methacrylate
Leaching
Sol-gels
dye
Coloring Agents
gel
Gels
leaching
Erythrosine
Dextrans
Glass
encapsulation
secondary structure
Molecular Weight
Macromolecules
Encapsulation
glass
Molecular weight
Molecules

Keywords

  • Dendrimer
  • Dye entrapment
  • Dye leaching
  • Optical sensor
  • Sol-gel

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Dye leaching from a doped sol-gel is eliminated by conjugation to a dendrimer. / Senarath-Yapa, Muditha D.; Saavedra, Steven S.

In: Analytica Chimica Acta, Vol. 432, No. 1, 22.03.2001, p. 89-94.

Research output: Contribution to journalArticle

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