TY - JOUR
T1 - Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats
AU - Pike, J. Wesley
AU - Parker, Jeffrey B.
AU - Haussler, Mark R.
AU - Boass, Agna
AU - Toverud, Svein U.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.
AB - The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.
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U2 - 10.1126/science.451573
DO - 10.1126/science.451573
M3 - Article
C2 - 451573
AN - SCOPUS:0018393813
VL - 204
SP - 1427
EP - 1429
JO - Science
JF - Science
SN - 0036-8075
IS - 4400
ER -