Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats

J. Wesley Pike, Jeffrey B. Parker, Mark R Haussler, Agna Boass, Svein U. Toverud

Research output: Contribution to journalArticle

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Abstract

The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.

Original languageEnglish (US)
Pages (from-to)1427-1429
Number of pages3
JournalScience
Volume204
Issue number4400
StatePublished - 1979

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Reproduction
Lactation
Calcium
Pregnancy
Parathyroidectomy
Weaning
Parathyroid Hormone
Serum
Vitamin D
Phosphorus
Parturition
Hormones
1,25-dihydroxyvitamin D

ASJC Scopus subject areas

  • General

Cite this

Pike, J. W., Parker, J. B., Haussler, M. R., Boass, A., & Toverud, S. U. (1979). Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats. Science, 204(4400), 1427-1429.

Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats. / Pike, J. Wesley; Parker, Jeffrey B.; Haussler, Mark R; Boass, Agna; Toverud, Svein U.

In: Science, Vol. 204, No. 4400, 1979, p. 1427-1429.

Research output: Contribution to journalArticle

Pike, JW, Parker, JB, Haussler, MR, Boass, A & Toverud, SU 1979, 'Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats', Science, vol. 204, no. 4400, pp. 1427-1429.
Pike JW, Parker JB, Haussler MR, Boass A, Toverud SU. Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats. Science. 1979;204(4400):1427-1429.
Pike, J. Wesley ; Parker, Jeffrey B. ; Haussler, Mark R ; Boass, Agna ; Toverud, Svein U. / Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats. In: Science. 1979 ; Vol. 204, No. 4400. pp. 1427-1429.
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abstract = "The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.",
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