Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats

J. Wesley Pike; Jeffrey B. Parker; Mark R. Haussler; Agna Boass; Svein U. Toverud

doi:10.1126/science.451573

Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats

J. Wesley Pike, Jeffrey B. Parker, Mark R. Haussler, Agna Boass, Svein U. Toverud

Basic Medical Sciences

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Abstract

The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)₂D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)₂D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)₂D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)₂D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)₂D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) ₂D during lactation.

Original language	English (US)
Pages (from-to)	1427-1429
Number of pages	3
Journal	Science
Volume	204
Issue number	4400
DOIs	https://doi.org/10.1126/science.451573
State	Published - Jan 1 1979

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title = "Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats",

abstract = "The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.",

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AU - Toverud, Svein U.

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