Abstract
The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1427-1429 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 204 |
| Issue number | 4400 |
| State | Published - 1979 |
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Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats. / Pike, J. Wesley; Parker, Jeffrey B.; Haussler, Mark R; Boass, Agna; Toverud, Svein U.
In: Science, Vol. 204, No. 4400, 1979, p. 1427-1429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats
AU - Pike, J. Wesley
AU - Parker, Jeffrey B.
AU - Haussler, Mark R
AU - Boass, Agna
AU - Toverud, Svein U.
PY - 1979
Y1 - 1979
N2 - The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.
AB - The concentrations of 1,25-dihydroxy vitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH) 2D during lactation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018393813&partnerID=8YFLogxK
M3 - Article
C2 - 451573
AN - SCOPUS:0018393813
VL - 204
SP - 1427
EP - 1429
JO - Science
JF - Science
SN - 0036-8075
IS - 4400
ER -