Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Ocular Melanoma as a Tool to Predict Metastatic Potential

Wenbo Wei, Guang Jia, Hendrik Von Tengg-Kobligk, Johannes T. Heverhagen, Mohamed Abdel-Rahman, Lai Wei, John B Christoforidis, Frederick Davidorf, Michael V. Knopp

Research output: Contribution to journalArticle

Abstract

Purpose This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management. Materials and Methods A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K trans (the transfer constant from the blood plasma to the extracellular space) and K ep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared. Metastasis was excluded by subsequent clinical work-up or confirmed by histology after targeted biopsy. Results Six patients were diagnosed with metastatic melanoma and 7 without. All orbital tumors were at least larger than 2 mm. A significant difference was identified in K trans between patients with (0.73 ± 0.18/min) and without (1.00 ± 0.21/min) metastatic melanoma (P = 0.03), whereas the difference was not significantly shown in K ep (2.58 ± 1.54/min of metastatic patients vs 2.98 ± 1.83/min of nonmetastatic patients, P = 0.67). Conclusions Dynamic contrast-enhanced magnetic resonance imaging has the potential to differentiate orbital melanomas with metastatic and nonmetastatic spread. Thus, DCE-MRI has the potential to be an in vivo imaging technique to predict early which patients are prone to metastatic disease.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume41
Issue number5
DOIs
StatePublished - Sep 1 2017

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Melanoma
Magnetic Resonance Imaging
Extracellular Space
Neoplasms
Histology
Head
Neoplasm Metastasis
Biopsy

Keywords

  • choroidal melanoma
  • dynamic contrast-enhanced magnetic resonance imaging
  • K trans
  • metastasis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Wei, W., Jia, G., Von Tengg-Kobligk, H., Heverhagen, J. T., Abdel-Rahman, M., Wei, L., ... Knopp, M. V. (2017). Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Ocular Melanoma as a Tool to Predict Metastatic Potential. Journal of Computer Assisted Tomography, 41(5), 823-827. https://doi.org/10.1097/RCT.0000000000000598

Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Ocular Melanoma as a Tool to Predict Metastatic Potential. / Wei, Wenbo; Jia, Guang; Von Tengg-Kobligk, Hendrik; Heverhagen, Johannes T.; Abdel-Rahman, Mohamed; Wei, Lai; Christoforidis, John B; Davidorf, Frederick; Knopp, Michael V.

In: Journal of Computer Assisted Tomography, Vol. 41, No. 5, 01.09.2017, p. 823-827.

Research output: Contribution to journalArticle

Wei, W, Jia, G, Von Tengg-Kobligk, H, Heverhagen, JT, Abdel-Rahman, M, Wei, L, Christoforidis, JB, Davidorf, F & Knopp, MV 2017, 'Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Ocular Melanoma as a Tool to Predict Metastatic Potential', Journal of Computer Assisted Tomography, vol. 41, no. 5, pp. 823-827. https://doi.org/10.1097/RCT.0000000000000598
Wei, Wenbo ; Jia, Guang ; Von Tengg-Kobligk, Hendrik ; Heverhagen, Johannes T. ; Abdel-Rahman, Mohamed ; Wei, Lai ; Christoforidis, John B ; Davidorf, Frederick ; Knopp, Michael V. / Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Ocular Melanoma as a Tool to Predict Metastatic Potential. In: Journal of Computer Assisted Tomography. 2017 ; Vol. 41, No. 5. pp. 823-827.
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abstract = "Purpose This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management. Materials and Methods A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K trans (the transfer constant from the blood plasma to the extracellular space) and K ep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared. Metastasis was excluded by subsequent clinical work-up or confirmed by histology after targeted biopsy. Results Six patients were diagnosed with metastatic melanoma and 7 without. All orbital tumors were at least larger than 2 mm. A significant difference was identified in K trans between patients with (0.73 ± 0.18/min) and without (1.00 ± 0.21/min) metastatic melanoma (P = 0.03), whereas the difference was not significantly shown in K ep (2.58 ± 1.54/min of metastatic patients vs 2.98 ± 1.83/min of nonmetastatic patients, P = 0.67). Conclusions Dynamic contrast-enhanced magnetic resonance imaging has the potential to differentiate orbital melanomas with metastatic and nonmetastatic spread. Thus, DCE-MRI has the potential to be an in vivo imaging technique to predict early which patients are prone to metastatic disease.",
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AU - Abdel-Rahman, Mohamed

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N2 - Purpose This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management. Materials and Methods A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K trans (the transfer constant from the blood plasma to the extracellular space) and K ep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared. Metastasis was excluded by subsequent clinical work-up or confirmed by histology after targeted biopsy. Results Six patients were diagnosed with metastatic melanoma and 7 without. All orbital tumors were at least larger than 2 mm. A significant difference was identified in K trans between patients with (0.73 ± 0.18/min) and without (1.00 ± 0.21/min) metastatic melanoma (P = 0.03), whereas the difference was not significantly shown in K ep (2.58 ± 1.54/min of metastatic patients vs 2.98 ± 1.83/min of nonmetastatic patients, P = 0.67). Conclusions Dynamic contrast-enhanced magnetic resonance imaging has the potential to differentiate orbital melanomas with metastatic and nonmetastatic spread. Thus, DCE-MRI has the potential to be an in vivo imaging technique to predict early which patients are prone to metastatic disease.

AB - Purpose This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management. Materials and Methods A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K trans (the transfer constant from the blood plasma to the extracellular space) and K ep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared. Metastasis was excluded by subsequent clinical work-up or confirmed by histology after targeted biopsy. Results Six patients were diagnosed with metastatic melanoma and 7 without. All orbital tumors were at least larger than 2 mm. A significant difference was identified in K trans between patients with (0.73 ± 0.18/min) and without (1.00 ± 0.21/min) metastatic melanoma (P = 0.03), whereas the difference was not significantly shown in K ep (2.58 ± 1.54/min of metastatic patients vs 2.98 ± 1.83/min of nonmetastatic patients, P = 0.67). Conclusions Dynamic contrast-enhanced magnetic resonance imaging has the potential to differentiate orbital melanomas with metastatic and nonmetastatic spread. Thus, DCE-MRI has the potential to be an in vivo imaging technique to predict early which patients are prone to metastatic disease.

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