Dynamic oxygenation measurements using a phosphorescent coating within a mammary window chamber mouse model

Rachel Schafer, Arthur F Gmitro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Phosphorescent lifetime imaging was employed to measure the spatial and temporal distribution of oxygen partial pressure in tissue under the coverslip of a mammary window chamber breast cancer mouse model. A thin platinum-porphyrin coating, whose phosphorescent lifetime varies monotonically with oxygen partial pressure, was applied to the coverslip surface. Dynamic temporal responses to induced modulations in oxygenation levels were measured using this approach.

Original languageEnglish (US)
Pages (from-to)639-650
Number of pages12
JournalBiomedical Optics Express
Volume6
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Partial Pressure
oxygenation
partial pressure
mice
Breast
chambers
Oxygen
coatings
life (durability)
temporal distribution
Porphyrins
oxygen
Platinum
porphyrins
breast
spatial distribution
platinum
cancer
Breast Neoplasms
modulation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Dynamic oxygenation measurements using a phosphorescent coating within a mammary window chamber mouse model. / Schafer, Rachel; Gmitro, Arthur F.

In: Biomedical Optics Express, Vol. 6, No. 2, 2015, p. 639-650.

Research output: Contribution to journalArticle

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