Dynamic states of adhering cancer cells under shear flow in an antibody-functionalized microchannel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Dynamic states of cancer cells moving under shear flow in an antibody-functionalized microchannel are investigated experimentally and theoretically. A simplified physical model was adopted to analyze the cell motion; it features a rigid sphere, with receptors on its surface, moving above a solid surface with distributed ligands. The cell motion is described by the Langevin equation where the hydrodynamic interactions, gravitational drift force, receptor-ligand binding force, and thermal fluctuations are all taken into account. The receptor-ligand bonds are modeled as Hookean springs. In this study, three dynamic states of cell motion have been identified: (i) free motion, (ii) rolling adhesion, and (iii) firm adhesion depending on the flow shear rate. The numerical simulations allow exploring effects of numerous parameters such as cell-receptor and surface-ligand density.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages849-852
Number of pages4
DOIs
Publication statusPublished - 2011
Event24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011 - Cancun, Mexico
Duration: Jan 23 2011Jan 27 2011

Other

Other24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011
CountryMexico
CityCancun
Period1/23/111/27/11

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Zheng, X. J., Cheung, L. S. L., Jiang, L., Schroeder, J., Heimark, R. L., Baygents, J. C., ... Zohar, Y. (2011). Dynamic states of adhering cancer cells under shear flow in an antibody-functionalized microchannel. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 849-852). [5734558] https://doi.org/10.1109/MEMSYS.2011.5734558