Dynorphin A analogs for the treatment of chronic neuropathic pain

Sara M. Hall, Yeon Sun Lee, Victor J Hruby

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Chronic pain is one of the most ubiquitous diseases in the world, but treatment is difficult with conventional methods, due to undesirable side effects of treatments and unknown mechanisms of pathological pain states. The endogenous peptide, dynorphin A has long been established as a target for the treatment of pain. Interestingly, this unique peptide has both inhibitory (opioid in nature) and excitatory activities (nonopioid) in the CNS. Both of these effects have been found to play a role in pain and much work has been done to develop therapeutics to enhance the inhibitory effects. Here we will review the dynorphin A compounds that have been designed for the modulation of pain and will discuss where the field stands today.

Original languageEnglish (US)
Pages (from-to)165-177
Number of pages13
JournalFuture Medicinal Chemistry
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2016

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ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

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