Early biological indicators of s-(1,2-dichlorovinyl)-l-cysteine nephrotoxicity in the rabbit

P. M. Silber, A Jay Gandolfi, K. Brendel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The progression of changes in rabbit kidney function following dosing with the nephrotoxin S-(1,2-dichlorovinyl)-L-cysteine (DCVC, 20-50 mg/kg) was determined. Proteinuria was observed 0.5-1 hr after administration of DCVC at doses of 20 -50 mg/kg. Blood urea nitrogen levels, glomerular filtration rates, urinary glucose excretion, and urine volume were also altered following DCVC dosing; however, these parameters were less sensitive than proteinuria as markers of early renal dysfunction. None of these latter four indicators were affected by low DCVC doses, nor were they altered by high DCVC doses until 1.5-2.5 hr after dosing. Dose-dependent morphological changes to kidney structure were also observed 5 hr after DCVC administration. Low doses caused damage restricted to brush border membranes in the pars recta, while higher doses produced a necrotic lesion encompassing all regions of the proximal tubule. This study indicates that DCVC can cause rapid renal dysfunctional changes which are first detected by elevated urinary protein excretion.

Original languageEnglish (US)
Pages (from-to)285-303
Number of pages19
JournalDrug and Chemical Toxicology
Volume9
Issue number3-4
DOIs
StatePublished - 1986

Fingerprint

Cysteine
Rabbits
Kidney
Brushes
Proteinuria
Urea
Glucose
Blood
Nitrogen
Proteins
Membranes
Blood Urea Nitrogen
Microvilli
Glomerular Filtration Rate
Rectum
Urine
S-(1,2-dichlorovinyl)cysteine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety
  • Chemistry(all)

Cite this

Early biological indicators of s-(1,2-dichlorovinyl)-l-cysteine nephrotoxicity in the rabbit. / Silber, P. M.; Gandolfi, A Jay; Brendel, K.

In: Drug and Chemical Toxicology, Vol. 9, No. 3-4, 1986, p. 285-303.

Research output: Contribution to journalArticle

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