Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery

Erwin B. Montgomery, William C. Koller, Theodora J.K. LaMantia, Mary C. Newman, Elizabeth Swanson-Hyland, Alfred W. Kaszniak, Kelly Lyons

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.

Original languageEnglish (US)
Pages (from-to)467-473
Number of pages7
JournalMovement Disorders
Volume15
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Diagnosis
  • Mood
  • Movement
  • Olfaction
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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