Early Heart Development

Paul A. Krieg, Andrew S. Warkman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The process of heart induction appears to be highly conserved among vertebrates. The endoderm is important for heart induction in vertebrates. The details of the mechanism remain poorly understood. The localized inhibition of canonical Wnt signaling, which is regulated by endogenous Wnt antagonists, is required for heart induction. The size of the developing heart is regulated by inhibitory signals. The bone morphogenetic protein (BMP), Wnt, fibroblast growth factor (FGF) and Notch signaling pathways are important during early heart development. Different transcription factor profiles, in different regions of the original heart field, direct differentiation of the individual subdomains of the developing heart. Using a defined set of transcription factors, it is now possible to reprogram non-cardiac cells to the myocardial lineage.

Original languageEnglish (US)
Title of host publicationPrinciples of Developmental Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages407-420
Number of pages14
ISBN (Print)9780124059450
DOIs
StatePublished - Jan 1 2015

Keywords

  • Bone morphogenetic protein (BMP)
  • Differentiation
  • Fibroblast growth factor (FGF)
  • Heart development
  • Heart induction
  • Notch
  • Signaling pathway
  • Transcription factor
  • Wnt
  • Wnt signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Krieg, P. A., & Warkman, A. S. (2015). Early Heart Development. In Principles of Developmental Genetics: Second Edition (pp. 407-420). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405945-0.00023-5