ECHO parameters of diastolic dysfunction

A. Schumacher, E. V. Khojeini, Douglas F Larson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Most patients with cardiac disease have diastolic dysfunction which is characterized by impaired diastolic filling and/or abnormal diastolic relaxation. The trans-esophageal echocardiography (TEE) used routinely during open-heart surgical procedures has exceptional resolution that may permit the identification and grading of diastolic dysfunction. The goal of this study was to determine which echocardiography (ECHO) parameters can best describe diastolic dysfunction due to myocardial remodeling and fibrosis. Baseline transthoracic ECHO was performed on 3-month-old C57BL/6J female mice followed by administration of isoproterenol (2 μg/g/d) for 6 days. On day 7, transthoracic ECHO was performed to determine the change of left ventricular (LV) inflow parameters due to isoproterenol-mediated cardiac remodeling. The mid-LV region was stained with picrosirius red to quantify myocardial fibrosis and demonstrated a 5-fold increase in cardiac fibrosis (p = 0.002). LV mass was increased by 36% (p = 0.0016). Mitral valve flow Doppler peak velocities E and A were measured from a 4-chamber view. The E/A ratio did not change, but the E deceleration time, velocity time integral of the E-A complex (E-A VTI), E/E-A VTI ratio, isovolumic relaxation time (IVRT), and diastolic time all significantly increased. The corresponding tissue Doppler parameter, Ea/Aa ratio, decreased by 25% (p = 0.035). The left atrial dimension and the ECHO index of left atrial pressure (E/Ea) significantly increased (p < 0.02). These data suggest that, with a long-axis and a 4-chamber view, the clinician can adequately determine diastolic function in the open-heart surgical patient.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalPerfusion
Volume23
Issue number5
DOIs
StatePublished - 2008

Fingerprint

Echocardiography
chamber
Fibrosis
Isoproterenol
Cardiac Surgical Procedures
grading
Atrial Pressure
Deceleration
Mitral Valve
Relaxation time
Heart Diseases
Disease
time
Tissue

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Advanced and Specialized Nursing
  • Safety Research

Cite this

ECHO parameters of diastolic dysfunction. / Schumacher, A.; Khojeini, E. V.; Larson, Douglas F.

In: Perfusion, Vol. 23, No. 5, 2008, p. 291-296.

Research output: Contribution to journalArticle

Schumacher, A, Khojeini, EV & Larson, DF 2008, 'ECHO parameters of diastolic dysfunction', Perfusion, vol. 23, no. 5, pp. 291-296. https://doi.org/10.1177/0267659109102485
Schumacher, A. ; Khojeini, E. V. ; Larson, Douglas F. / ECHO parameters of diastolic dysfunction. In: Perfusion. 2008 ; Vol. 23, No. 5. pp. 291-296.
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