Economic burden associated with the use of generic antiepileptic drugs in the United States

Sandra L. Helmers, Pierre Emmanuel Paradis, Ranjani Manjunath, Mei Sheng Duh, Marie Hélène Lafeuille, Dominick Latrémouille-Viau, Patrick Lefebvre, David M. Labiner

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


This study quantifies the economic burden associated with generic-versus-branded use of antiepileptic drugs (AEDs) in the United States. Adult patients with epilepsy receiving carbamazepine, gabapentin, phenytoin, primidone, or zonisamide were selected from the PharMetrics database. By use of an open-cohort design, patients were classified into mutually exclusive periods of generic-versus-branded AED use. Annualized cost differences (CDs) between periods were estimated using multivariate regressions. Results were stratified into stable versus unstable epilepsy and newer-generation versus older-generation AEDs. A total of 33,625 patients (52% male, mean age. = 51 years) were observed. Periods of generic AED treatment were associated with higher medical service costs (adjusted CD [95% CI]. = $3186 [$2359; $4012]), stable pharmacy costs ($69 [$-34; $171]), and greater total costs ($3254 [$2403; $4105]) versus brand use. Epilepsy-related costs represented 30% of incremental costs. Similar findings were observed for patients with stable and unstable epilepsy and users of newer-generation and older-generation AEDs. Significantly higher health care costs were observed during generic AED use across seizure control and AED subgroups.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalEpilepsy and Behavior
Issue number4
StatePublished - Aug 2010


  • Antiepileptic drugs
  • Economic analysis
  • Epilepsy
  • Generic substitution

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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