Effect of β-carotene on lymphocyte subpopulations in elderly humans: Evidence for a dose-response relationship

Ronald R. Watson, Rao H. Prabhala, Patricia M. Plezia, David S. Alberts

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

The effects of various doses (0, 15, 30, 45, and 60 mg/d) of supplementary β-carotene were evaluated. The percentage of lymphoid cells with surface markers for T-helper and natural killer (NK) cells and cells with interleukin 2 (IL-2) and transferrin receptors were significantly and substantially increased in peripheral blood mononuclear cells collected from older human adult volunteers after supplementation with ≥ 30 mg β-carotene/d for 2 mo. The increase in the percentage of cells with markers of NK cells and in expression of IL-2 receptors was dose dependent. The plasma concentrations of β-carotene were also elevated significantly; however, there was no increase in the amount of retinol present in plasma. This indicated that immunomodulation induced by β-carotene may be due to the carotenoid rather than to an increased amount, and hence actions, of vitamin A. These results support the role of immunostimulation as a potential mechanism of action of β-carotene with cancer-prevention potential.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume53
Issue number1
StatePublished - Jan 1991

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Lymphocyte Subsets
Carotenoids
carotenes
dose response
lymphocytes
natural killer cells
interleukin-2
Interleukin-2 Receptors
vitamin A
Vitamin A
immunostimulation (physiological)
receptors
immunomodulation
transferrin
cells
mononuclear leukocytes
dosage
Natural Killer T-Cells
Transferrin Receptors
Immunomodulation

Keywords

  • Beta-carotene
  • Interleukin 2 receptors
  • Natural killer cells
  • Plasma concentrations
  • Retinol
  • T lymphocytes

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Effect of β-carotene on lymphocyte subpopulations in elderly humans : Evidence for a dose-response relationship. / Watson, Ronald R.; Prabhala, Rao H.; Plezia, Patricia M.; Alberts, David S.

In: American Journal of Clinical Nutrition, Vol. 53, No. 1, 01.1991, p. 90-94.

Research output: Contribution to journalArticle

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