Effect of acute alpha adrenergic stimulation on cardiac function

Stacy Dunaway, Qianli Yu, Douglas F Larson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background. Phenylephrine (PE) is a α-adrenergic agent commonly administered by perfusion and anesthesia. It is important to identify the effect of PE, especially on cardiac function. This study was intended to show the effects of PE on cardiac function in the murine model via pressure-volume loops. Methods. Six C57BL/6J twelve-week-old female mice were studied prior to and following PE administration at 50 μg/kg IV. In vivo pressure-volume loops were recorded at both time points. Results. There was an expected increase in maximum arterial pressure by 30% (p < 0.001) and end-systolic pressure by 34% (p < 0.001). However, there was a decrease in cardiac output by 30% (p = 0.0006), ejection fraction by 36% (p - 0.0003) and stroke volume by 25% (p < 0.004). Conclusions. This study demonstrates that PE has an effect on cardiac function beyond increasing vascular resistance. The data suggest the negative effects of PE on cardiac function may be related to stimulation of cardiac α-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalPerfusion
Volume22
Issue number4
DOIs
StatePublished - 2007

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Phenylephrine
Adrenergic Agents
stroke
Pressure
Cardiac Output
Vascular Resistance
Stroke Volume
Adrenergic Receptors
Arterial Pressure
Anesthesia
Perfusion
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of acute alpha adrenergic stimulation on cardiac function. / Dunaway, Stacy; Yu, Qianli; Larson, Douglas F.

In: Perfusion, Vol. 22, No. 4, 2007, p. 289-292.

Research output: Contribution to journalArticle

Dunaway, Stacy ; Yu, Qianli ; Larson, Douglas F. / Effect of acute alpha adrenergic stimulation on cardiac function. In: Perfusion. 2007 ; Vol. 22, No. 4. pp. 289-292.
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