Effect of acute challenge with an extreme dose of somatotropin in a prolonged-release formulation on milk production and health of dairy cattle.

J. L. Vicini, S. Hudson, W. J. Cole, M. A. Miller, P. J. Eppard, T. C. White, Robert J Collier

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Eight pregnant Holstein cows were given weekly injections of 15 g of recombinant bST over a 2-wk period for a total dose of 30 g to determine signs of acute toxicity. Cows were monitored intensively throughout the study, and samples were taken for analyses of hormones, metabolites, chemistries, hematology, and urine analytes. Animal health throughout the study was generally excellent. Mean rectal temperatures were significantly higher in treated cows (38.7 vs. 39.2 degrees C). Least squares means for 3.5% FCM production were 15.9 and 23.0 kg/d, and net energy intakes were 29.4 and 26.9 Mcal/d for control and treated cows, respectively. Somatotropin concentrations reached more than 250 ng/ml on d 10 and remained above 200 ng/ml. Insulin and glucose concentrations were also increased but returned toward baseline values. Free fatty acid concentrations were higher in treated cows, but beta-hydroxybutyrate was not affected. Most hematological measurements were unaffected except for a reduction in erythrocyte number in treated cows and decreases in hematocrit and hemoglobin, but values were within clinically normal ranges. Although cows received in 2 wk a dose that was equivalent to the amount administered during more than 2 yr of continuous use, no signs of acute toxicity to bST were observed.

Original languageEnglish (US)
Pages (from-to)2093-2102
Number of pages10
JournalJournal of Dairy Science
Volume73
Issue number8
StatePublished - Aug 1990
Externally publishedYes

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Erythrocyte Count
3-Hydroxybutyric Acid
Hematology
Energy Intake
Least-Squares Analysis
Hematocrit
Nonesterified Fatty Acids
somatotropin
Growth Hormone
dairy cattle
milk production
Milk
Reference Values
Hemoglobins
Urine
Hormones
Insulin
Glucose
cows
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of acute challenge with an extreme dose of somatotropin in a prolonged-release formulation on milk production and health of dairy cattle. / Vicini, J. L.; Hudson, S.; Cole, W. J.; Miller, M. A.; Eppard, P. J.; White, T. C.; Collier, Robert J.

In: Journal of Dairy Science, Vol. 73, No. 8, 08.1990, p. 2093-2102.

Research output: Contribution to journalArticle

Vicini, J. L. ; Hudson, S. ; Cole, W. J. ; Miller, M. A. ; Eppard, P. J. ; White, T. C. ; Collier, Robert J. / Effect of acute challenge with an extreme dose of somatotropin in a prolonged-release formulation on milk production and health of dairy cattle. In: Journal of Dairy Science. 1990 ; Vol. 73, No. 8. pp. 2093-2102.
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