Effect of age on Agaricus bisporus PHA-B stimulated insulin release and45Ca2+ uptake in vitro by islets of langerhans

Nafees Ahmad, M. Mubin Khan, Anil K. Rastogi, Jalil R. Kidwal

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The in vitro basal insulin release and45Ca2+ uptake by rat islets of Langerhans remain unaffected by the animal's age. However, when Agaricus bisporus lectin PHA-B is added to the medium, there is a significant stimulation of basal insulin secretion and45Ca2+ uptake. The islets isolated from younger rats are more sensitive to A. bisporus PHA-B stimulation and register 1.5-fold and 3-fold more increases of insulin release and45Ca2+ uptake respectively as compared to islets isolated from 12-month-old rats. Age-related conformational changes in the B-cell membrane are suggested as a possible explanation for the above observation.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalActa Diabetologica Latina
Issue number4
StatePublished - Oct 1 1984
Externally publishedYes


  • Agaricus bisporus PHA-B
  • Ca
  • Insulin release
  • Islets of Langerhans

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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