Effect of age on Agaricus bisporus PHA-B stimulated insulin release and45Ca2+ uptake in vitro by islets of langerhans

Nafees - Ahmad, M. Mubin Khan, Anil K. Rastogi, Jalil R. Kidwal

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The in vitro basal insulin release and45Ca2+ uptake by rat islets of Langerhans remain unaffected by the animal's age. However, when Agaricus bisporus lectin PHA-B is added to the medium, there is a significant stimulation of basal insulin secretion and45Ca2+ uptake. The islets isolated from younger rats are more sensitive to A. bisporus PHA-B stimulation and register 1.5-fold and 3-fold more increases of insulin release and45Ca2+ uptake respectively as compared to islets isolated from 12-month-old rats. Age-related conformational changes in the B-cell membrane are suggested as a possible explanation for the above observation.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalActa Diabetologica Latina
Volume21
Issue number4
DOIs
StatePublished - Oct 1984
Externally publishedYes

Fingerprint

Agaricus
Islets of Langerhans
Insulin
B-Lymphocytes
Cell Membrane
Observation
B-insulin
In Vitro Techniques

Keywords

  • Ca
  • Agaricus bisporus PHA-B
  • Insulin release
  • Islets of Langerhans

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Effect of age on Agaricus bisporus PHA-B stimulated insulin release and45Ca2+ uptake in vitro by islets of langerhans. / Ahmad, Nafees -; Khan, M. Mubin; Rastogi, Anil K.; Kidwal, Jalil R.

In: Acta Diabetologica Latina, Vol. 21, No. 4, 10.1984, p. 349-355.

Research output: Contribution to journalArticle

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AU - Kidwal, Jalil R.

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