Effect of Age on Procedural Success, Complications, and Clinical Outcome From a Large Angioplasty Registry

Mehdi Mousavi, Hamidreza Poorhosseini, Ebrahim Nematipour, Seyed Ebrahim Kassaian, Mojtaba Salarifar, Mohammad Alidoosti, Alimohammad Hajizeinali, Younes Nozari, Alireza Amirzadegan, Seyed Kianoosh Hosseini, Mahamood Sheikh Fathollahi, Mohammad R Movahed

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Increasing age appears to be a risk factor for adverse outcome in patients undergoing percutaneous coronary intervention (PCI). The goal of this study was to compare procedural success, complications, and 12 months major adverse cardiac events (MACE) based on age using a large angioplasty registry. METHODS: This registry included 10,412 patients with at least 12-month follow-up from April 1993 to April 2011. Patients were divided into 3 age groups: group 1 age < 60 (n = 6195), group 2 age 60-75 (n = 3724) and group 3 elderly age ≥ 75 (n = 493). RESULTS: Procedural success rate was not significantly different across the 3 age groups. (96.9% in group 1, 97.1% in group 2, and 96.1% in elderly group, P = 0.759). Procedural complications occurred in 179 (2.9%) of group 1, 98 (2.6%) of group 2 and 15 (3.0%) of elderly group (P = 0.678). In-hospital complications increased with increasing age (311 [5.0%] in group 1, 235 [6.3%] in group 2, and 46 [9.3%] in elderly group; P < 0.001). Twelve-month MACE also increased with increasing age (235 [4.1%] in group 1, 169 [4.9%] in group 2 and 26 [5.7%] in elderly group; P = 0.021). Multivariate analysis showed that age was not a predictor for unsuccessful PCI, procedural complications, or 12-month MACE. However, increasing age was independent predictors of in-hospital complications and death. CONCLUSION: Despite increased in-hospital complications with increasing age, procedural success, and complications were not higher in elderly. Our data suggest that PCI should not be denied in elderly if indicated with procedural safety similar to other age groups.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalCritical pathways in cardiology
Volume18
Issue number1
DOIs
StatePublished - Mar 1 2019

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Angioplasty
Registries
Age Groups
Percutaneous Coronary Intervention
Multivariate Analysis
Safety

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of Age on Procedural Success, Complications, and Clinical Outcome From a Large Angioplasty Registry. / Mousavi, Mehdi; Poorhosseini, Hamidreza; Nematipour, Ebrahim; Kassaian, Seyed Ebrahim; Salarifar, Mojtaba; Alidoosti, Mohammad; Hajizeinali, Alimohammad; Nozari, Younes; Amirzadegan, Alireza; Hosseini, Seyed Kianoosh; Fathollahi, Mahamood Sheikh; Movahed, Mohammad R.

In: Critical pathways in cardiology, Vol. 18, No. 1, 01.03.2019, p. 23-31.

Research output: Contribution to journalArticle

Mousavi, M, Poorhosseini, H, Nematipour, E, Kassaian, SE, Salarifar, M, Alidoosti, M, Hajizeinali, A, Nozari, Y, Amirzadegan, A, Hosseini, SK, Fathollahi, MS & Movahed, MR 2019, 'Effect of Age on Procedural Success, Complications, and Clinical Outcome From a Large Angioplasty Registry', Critical pathways in cardiology, vol. 18, no. 1, pp. 23-31. https://doi.org/10.1097/HPC.0000000000000158
Mousavi, Mehdi ; Poorhosseini, Hamidreza ; Nematipour, Ebrahim ; Kassaian, Seyed Ebrahim ; Salarifar, Mojtaba ; Alidoosti, Mohammad ; Hajizeinali, Alimohammad ; Nozari, Younes ; Amirzadegan, Alireza ; Hosseini, Seyed Kianoosh ; Fathollahi, Mahamood Sheikh ; Movahed, Mohammad R. / Effect of Age on Procedural Success, Complications, and Clinical Outcome From a Large Angioplasty Registry. In: Critical pathways in cardiology. 2019 ; Vol. 18, No. 1. pp. 23-31.
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abstract = "BACKGROUND: Increasing age appears to be a risk factor for adverse outcome in patients undergoing percutaneous coronary intervention (PCI). The goal of this study was to compare procedural success, complications, and 12 months major adverse cardiac events (MACE) based on age using a large angioplasty registry. METHODS: This registry included 10,412 patients with at least 12-month follow-up from April 1993 to April 2011. Patients were divided into 3 age groups: group 1 age < 60 (n = 6195), group 2 age 60-75 (n = 3724) and group 3 elderly age ≥ 75 (n = 493). RESULTS: Procedural success rate was not significantly different across the 3 age groups. (96.9{\%} in group 1, 97.1{\%} in group 2, and 96.1{\%} in elderly group, P = 0.759). Procedural complications occurred in 179 (2.9{\%}) of group 1, 98 (2.6{\%}) of group 2 and 15 (3.0{\%}) of elderly group (P = 0.678). In-hospital complications increased with increasing age (311 [5.0{\%}] in group 1, 235 [6.3{\%}] in group 2, and 46 [9.3{\%}] in elderly group; P < 0.001). Twelve-month MACE also increased with increasing age (235 [4.1{\%}] in group 1, 169 [4.9{\%}] in group 2 and 26 [5.7{\%}] in elderly group; P = 0.021). Multivariate analysis showed that age was not a predictor for unsuccessful PCI, procedural complications, or 12-month MACE. However, increasing age was independent predictors of in-hospital complications and death. CONCLUSION: Despite increased in-hospital complications with increasing age, procedural success, and complications were not higher in elderly. Our data suggest that PCI should not be denied in elderly if indicated with procedural safety similar to other age groups.",
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T1 - Effect of Age on Procedural Success, Complications, and Clinical Outcome From a Large Angioplasty Registry

AU - Mousavi, Mehdi

AU - Poorhosseini, Hamidreza

AU - Nematipour, Ebrahim

AU - Kassaian, Seyed Ebrahim

AU - Salarifar, Mojtaba

AU - Alidoosti, Mohammad

AU - Hajizeinali, Alimohammad

AU - Nozari, Younes

AU - Amirzadegan, Alireza

AU - Hosseini, Seyed Kianoosh

AU - Fathollahi, Mahamood Sheikh

AU - Movahed, Mohammad R

PY - 2019/3/1

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N2 - BACKGROUND: Increasing age appears to be a risk factor for adverse outcome in patients undergoing percutaneous coronary intervention (PCI). The goal of this study was to compare procedural success, complications, and 12 months major adverse cardiac events (MACE) based on age using a large angioplasty registry. METHODS: This registry included 10,412 patients with at least 12-month follow-up from April 1993 to April 2011. Patients were divided into 3 age groups: group 1 age < 60 (n = 6195), group 2 age 60-75 (n = 3724) and group 3 elderly age ≥ 75 (n = 493). RESULTS: Procedural success rate was not significantly different across the 3 age groups. (96.9% in group 1, 97.1% in group 2, and 96.1% in elderly group, P = 0.759). Procedural complications occurred in 179 (2.9%) of group 1, 98 (2.6%) of group 2 and 15 (3.0%) of elderly group (P = 0.678). In-hospital complications increased with increasing age (311 [5.0%] in group 1, 235 [6.3%] in group 2, and 46 [9.3%] in elderly group; P < 0.001). Twelve-month MACE also increased with increasing age (235 [4.1%] in group 1, 169 [4.9%] in group 2 and 26 [5.7%] in elderly group; P = 0.021). Multivariate analysis showed that age was not a predictor for unsuccessful PCI, procedural complications, or 12-month MACE. However, increasing age was independent predictors of in-hospital complications and death. CONCLUSION: Despite increased in-hospital complications with increasing age, procedural success, and complications were not higher in elderly. Our data suggest that PCI should not be denied in elderly if indicated with procedural safety similar to other age groups.

AB - BACKGROUND: Increasing age appears to be a risk factor for adverse outcome in patients undergoing percutaneous coronary intervention (PCI). The goal of this study was to compare procedural success, complications, and 12 months major adverse cardiac events (MACE) based on age using a large angioplasty registry. METHODS: This registry included 10,412 patients with at least 12-month follow-up from April 1993 to April 2011. Patients were divided into 3 age groups: group 1 age < 60 (n = 6195), group 2 age 60-75 (n = 3724) and group 3 elderly age ≥ 75 (n = 493). RESULTS: Procedural success rate was not significantly different across the 3 age groups. (96.9% in group 1, 97.1% in group 2, and 96.1% in elderly group, P = 0.759). Procedural complications occurred in 179 (2.9%) of group 1, 98 (2.6%) of group 2 and 15 (3.0%) of elderly group (P = 0.678). In-hospital complications increased with increasing age (311 [5.0%] in group 1, 235 [6.3%] in group 2, and 46 [9.3%] in elderly group; P < 0.001). Twelve-month MACE also increased with increasing age (235 [4.1%] in group 1, 169 [4.9%] in group 2 and 26 [5.7%] in elderly group; P = 0.021). Multivariate analysis showed that age was not a predictor for unsuccessful PCI, procedural complications, or 12-month MACE. However, increasing age was independent predictors of in-hospital complications and death. CONCLUSION: Despite increased in-hospital complications with increasing age, procedural success, and complications were not higher in elderly. Our data suggest that PCI should not be denied in elderly if indicated with procedural safety similar to other age groups.

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