Effect of amiodarone on haemodynamics during cardiopulmonary resuscitation in a canine model of resistant ventricular fibrillation

Edison F. Paiva, Maria Beatriz M Perondi, Karl B Kern, Robert A. Berg, Sergio Timerman, Luiz F. Cardoso, José Antonio F Ramirez

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Amiodarone has been shown to be superior to both placebo and lidocaine in improving survival to hospital admission for victims of out-of-hospital refractory ventricular fibrillation. Concern had been expressed about the known vasodilatatory effects of amiodarone if given without precedent vasoconstrictive medications. The haemodynamic effects of intravenous amiodarone administered during ongoing CPR have not been systemically investigated. Our intention was to verify if amiodarone alone produced significantly lower resuscitation haemodynamics than did either adrenaline (epinephrine) alone or the combination of amiodarone and adrenaline. Design: Prospective, randomized, comparative study. Setting: Research laboratory of a medical school. Subjects: Thirty mongrel dogs. Interventions: After 8 min of untreated VF, defibrillation was attempted once at 3 J/kg and external chest compressions and ventilation started. Those animals resistant to the defibrillation attempt were randomized, ten to an adrenaline (0.02 mg/kg) group, ten to an amiodarone (5 mg/kg) group, and ten to a group receiving a combination of both drugs. Measurements and main results: Aortic systolic and diastolic, and coronary perfusion pressures were all significantly lower in the group receiving amiodarone alone than in the other two groups. Amiodarone combined with adrenaline produced pressures during CPR similar to adrenaline alone. Conclusion: Amiodarone can be safely administered simultaneously in combination with adrenaline and such a combination results in similar haemodynamic support as adrenaline alone. Amiodarone administered alone produces significantly lower coronary perfusion pressure than when combined with adrenaline.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalResuscitation
Volume58
Issue number2
DOIs
StatePublished - Aug 2003

Fingerprint

Amiodarone
Cardiopulmonary Resuscitation
Ventricular Fibrillation
Canidae
Epinephrine
Hemodynamics
Pressure
Perfusion
Drug Combinations
Lidocaine
Medical Schools
Resuscitation
Ventilation
Thorax
Placebos
Dogs

Keywords

  • Amiodarone
  • Cardiopulmonary resuscitation
  • Coronary perfusion pressure
  • Ventricular fibrillation, cardiac arrest

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

Effect of amiodarone on haemodynamics during cardiopulmonary resuscitation in a canine model of resistant ventricular fibrillation. / Paiva, Edison F.; Perondi, Maria Beatriz M; Kern, Karl B; Berg, Robert A.; Timerman, Sergio; Cardoso, Luiz F.; Ramirez, José Antonio F.

In: Resuscitation, Vol. 58, No. 2, 08.2003, p. 203-208.

Research output: Contribution to journalArticle

Paiva, Edison F. ; Perondi, Maria Beatriz M ; Kern, Karl B ; Berg, Robert A. ; Timerman, Sergio ; Cardoso, Luiz F. ; Ramirez, José Antonio F. / Effect of amiodarone on haemodynamics during cardiopulmonary resuscitation in a canine model of resistant ventricular fibrillation. In: Resuscitation. 2003 ; Vol. 58, No. 2. pp. 203-208.
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AU - Perondi, Maria Beatriz M

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AU - Berg, Robert A.

AU - Timerman, Sergio

AU - Cardoso, Luiz F.

AU - Ramirez, José Antonio F

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AB - Objective: Amiodarone has been shown to be superior to both placebo and lidocaine in improving survival to hospital admission for victims of out-of-hospital refractory ventricular fibrillation. Concern had been expressed about the known vasodilatatory effects of amiodarone if given without precedent vasoconstrictive medications. The haemodynamic effects of intravenous amiodarone administered during ongoing CPR have not been systemically investigated. Our intention was to verify if amiodarone alone produced significantly lower resuscitation haemodynamics than did either adrenaline (epinephrine) alone or the combination of amiodarone and adrenaline. Design: Prospective, randomized, comparative study. Setting: Research laboratory of a medical school. Subjects: Thirty mongrel dogs. Interventions: After 8 min of untreated VF, defibrillation was attempted once at 3 J/kg and external chest compressions and ventilation started. Those animals resistant to the defibrillation attempt were randomized, ten to an adrenaline (0.02 mg/kg) group, ten to an amiodarone (5 mg/kg) group, and ten to a group receiving a combination of both drugs. Measurements and main results: Aortic systolic and diastolic, and coronary perfusion pressures were all significantly lower in the group receiving amiodarone alone than in the other two groups. Amiodarone combined with adrenaline produced pressures during CPR similar to adrenaline alone. Conclusion: Amiodarone can be safely administered simultaneously in combination with adrenaline and such a combination results in similar haemodynamic support as adrenaline alone. Amiodarone administered alone produces significantly lower coronary perfusion pressure than when combined with adrenaline.

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