Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild Norway rats

N. K. Popova, Ella M Nikulina, S. N. Shigantsov, I. F. Plyusnina, T. G. Amstislavskaya

Research output: Contribution to journalArticle

Abstract

The effect of agonists of serotonin receptors on predator aggressiveness (the "mouse killing" test) is studied on Norway rats. Ipsapirone and eltoprazine are found to have no effect on predator aggressiveness. 1-[3-(Trifluoromethyl)phenyl]piperazine x HCl (TFMPP) considerably reduces aggressiveness. The serotonin precursor 5-hydroxyptryptophan also lowers it, while the antagonist of 5-HT2A receptors ketanserin abolishes the inhibitory effect of 5-hydroxytryptophan. Presumably, the inhibitory effects of serotonin on predator aggressiveness are realized via the 5-HT2A and 5-HT2C brain serotonin receptors.

Original languageEnglish (US)
Pages (from-to)621-623
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume121
Issue number6
StatePublished - Jun 1996
Externally publishedYes

Fingerprint

Serotonin 5-HT2 Receptors
Serotonin 5-HT1 Receptor Antagonists
Serotonin 5-HT1 Receptor Agonists
Rats
Serotonin
Receptor, Serotonin, 5-HT2C
Receptor, Serotonin, 5-HT2A
5-Hydroxytryptophan
Ketanserin
Serotonin Receptor Agonists
Serotonin Receptors
Brain

Keywords

  • Predator aggressiveness
  • Types of serotonin receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild Norway rats. / Popova, N. K.; Nikulina, Ella M; Shigantsov, S. N.; Plyusnina, I. F.; Amstislavskaya, T. G.

In: Bulletin of Experimental Biology and Medicine, Vol. 121, No. 6, 06.1996, p. 621-623.

Research output: Contribution to journalArticle

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