Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild Norway rats

N. K. Popova, E. M. Nikulina, S. N. Shigantsov, I. F. Plyusnina, T. G. Amstislavskaya

Research output: Contribution to journalArticlepeer-review


The effect of agonists of serotonin receptors on predator aggressiveness (the "mouse killing" test) is studied on Norway rats. Ipsapirone and eltoprazine are found to have no effect on predator aggressiveness. 1-[3-(Trifluoromethyl)phenyl]piperazine x HCl (TFMPP) considerably reduces aggressiveness. The serotonin precursor 5-hydroxyptryptophan also lowers it, while the antagonist of 5-HT2A receptors ketanserin abolishes the inhibitory effect of 5-hydroxytryptophan. Presumably, the inhibitory effects of serotonin on predator aggressiveness are realized via the 5-HT2A and 5-HT2C brain serotonin receptors.

Original languageEnglish (US)
Pages (from-to)621-623
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number6
StatePublished - Jun 1996
Externally publishedYes


  • Predator aggressiveness
  • Types of serotonin receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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