Effect of bepridil in patients with chronic stable angina: Results of a multicenter trial

J. A. Hill, J. T. O'Brien, J. S. Alpert, J. M. Gore, R. M. Zusman, D. Christensen, C. A. Boucher, G. Vetrovec, J. S. Borer, C. Friedman

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The effects of bepridil, a calcium antagonist with a half-life of approximately 42 hr, were assessed in a double-blind, randomized, placebo-controlled crossover trial. Forty-four patients (39 men, five women) with exercise-induced angina pectoris and ST segment depression with exercise testing (modified Bruce protocol) were studied. Compared with placebo bepridil (400 mg daily) increased total exercise time, time to onset of angina, time to 1 mm of ST segment depression, time to 2 mm of ST segment depression, and total work achieved (all p ≤ .001). Both frequency of angina and nitroglycerin consumption decreased during the bepridil compared with the placebo period (p = .02 and .03, respectively). Minor side effects were noted during both the bepridil and placebo phases. Four patients experienced side effects that limited therapy (dizziness in three and abnormal results of liver function tests in one) and one patient died during the bepridil phase. This study suggests that bepridil, 400 mg daily, is effective for the treatment of exercise-induced myocardial ischemia and angina pectoris.

Original languageEnglish (US)
Pages (from-to)98-103
Number of pages6
JournalCirculation
Volume71
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Hill, J. A., O'Brien, J. T., Alpert, J. S., Gore, J. M., Zusman, R. M., Christensen, D., Boucher, C. A., Vetrovec, G., Borer, J. S., & Friedman, C. (1985). Effect of bepridil in patients with chronic stable angina: Results of a multicenter trial. Circulation, 71(1), 98-103. https://doi.org/10.1161/01.CIR.71.1.98