Effect of Bovine Somatotropin Administered to Periparturient Dairy Cows on the Incidence of Metabolic Disease

P. J. Eppard, J. J. Veenhuizen, W. J. Cole, P. G. Comens-Keller, G. F. Hartnell, R. L. Hintz, L. Munyakazi, P. K. Olsson, R. H. Sorbet, T. C. White, C. A. Baile, Robert J Collier, J. P. Goff, R. L. Horst

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Thirty-eight dry, pregnant Jersey cows were assigned to diet and bST treatment in a 2 × 2 factorial design. During the dry period, half of the cows were fed a normal TMR (0.4% Ca; 0.3 to 0.4% P), and half of the cows were fed a high Ca TMR (1.5 to 1.6% Ca; 0.4 to 0.7% P). The high Ca diets were designed to induce milk fever and were relatively cationic (194 to 293 meq/kg) compared with the normal diets (-131 to 30 meq/kg). A standard dairy diet was fed to all cows postcalving. Cows received subcutaneous injections of either an oil-based excipient or 500 mg of bST in an oil-based excipient every 14 d from 28 d before expected calving until approximately 14 d postcalving. Peripartal bST treatment decreased the incidence of clinical mastitis, did not affect incidence of milk fever, and increased the duration, but not the incidence, of ketosis in mature Jersey cows. Blood data confirmed the clinical responses and indicated that treated cows mobilized more bone Ca than did controls, as was evidenced by increased hydroxyproline concentrations. Treatment with bST did not affect blood concentrations of 1,25-dihydroxyvitamin D, Ca, or Mg. High Ca diets increased the incidence of milk fever and downer cow syndrome compared with normal diets. The effect of bST on mastitis and milk production must be considered as preliminary given the small size of the study. Although bST treatment increased Ca mobilization, the effect was insufficient to prevent milk fever in this model.

Original languageEnglish (US)
Pages (from-to)2170-2181
Number of pages12
JournalJournal of Dairy Science
Volume79
Issue number12
StatePublished - 1996
Externally publishedYes

Fingerprint

Metabolic Diseases
metabolic diseases
somatotropin
dairy cows
Diet
Milk
cows
incidence
milk fever
Incidence
Fever
Mastitis
Excipients
diet
Oils
Jersey
mastitis
Ketosis
Hydroxyproline
Subcutaneous Injections

Keywords

  • Bovine somatotropin
  • Lactation
  • Mastitis
  • Milk fever

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)

Cite this

Eppard, P. J., Veenhuizen, J. J., Cole, W. J., Comens-Keller, P. G., Hartnell, G. F., Hintz, R. L., ... Horst, R. L. (1996). Effect of Bovine Somatotropin Administered to Periparturient Dairy Cows on the Incidence of Metabolic Disease. Journal of Dairy Science, 79(12), 2170-2181.

Effect of Bovine Somatotropin Administered to Periparturient Dairy Cows on the Incidence of Metabolic Disease. / Eppard, P. J.; Veenhuizen, J. J.; Cole, W. J.; Comens-Keller, P. G.; Hartnell, G. F.; Hintz, R. L.; Munyakazi, L.; Olsson, P. K.; Sorbet, R. H.; White, T. C.; Baile, C. A.; Collier, Robert J; Goff, J. P.; Horst, R. L.

In: Journal of Dairy Science, Vol. 79, No. 12, 1996, p. 2170-2181.

Research output: Contribution to journalArticle

Eppard, PJ, Veenhuizen, JJ, Cole, WJ, Comens-Keller, PG, Hartnell, GF, Hintz, RL, Munyakazi, L, Olsson, PK, Sorbet, RH, White, TC, Baile, CA, Collier, RJ, Goff, JP & Horst, RL 1996, 'Effect of Bovine Somatotropin Administered to Periparturient Dairy Cows on the Incidence of Metabolic Disease', Journal of Dairy Science, vol. 79, no. 12, pp. 2170-2181.
Eppard PJ, Veenhuizen JJ, Cole WJ, Comens-Keller PG, Hartnell GF, Hintz RL et al. Effect of Bovine Somatotropin Administered to Periparturient Dairy Cows on the Incidence of Metabolic Disease. Journal of Dairy Science. 1996;79(12):2170-2181.
Eppard, P. J. ; Veenhuizen, J. J. ; Cole, W. J. ; Comens-Keller, P. G. ; Hartnell, G. F. ; Hintz, R. L. ; Munyakazi, L. ; Olsson, P. K. ; Sorbet, R. H. ; White, T. C. ; Baile, C. A. ; Collier, Robert J ; Goff, J. P. ; Horst, R. L. / Effect of Bovine Somatotropin Administered to Periparturient Dairy Cows on the Incidence of Metabolic Disease. In: Journal of Dairy Science. 1996 ; Vol. 79, No. 12. pp. 2170-2181.
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