Effect of calcium and vitamin D supplementation on blood pressure: The women's health initiative randomized trial

Karen L. Margolis, Roberta M. Ray, Linda Van Horn, Jo Ann E. Manson, Matthew A. Allison, Henry R. Black, Shirley A.A. Beresford, Stephanie A. Connelly, J. David Curb, Richard H. Grimm, Theodore A. Kotchen, Lewis H. Kuller, Sylvia Wassertheil-Smoller, Cynthia A. Thomson, James C. Torner

Research output: Contribution to journalArticle

196 Scopus citations

Abstract

Experimental and epidemiological studies suggest that calcium and vitamin D supplements may lower blood pressure. We examined the effect of calcium plus vitamin D supplementation on blood pressure and the incidence of hypertension in postmenopausal women. The Women's Health Initiative Calcium/Vitamin D Trial randomly assigned 36 282 postmenopausal women to receive 1000 mg of elemental calcium plus 400IU of vitamin D3 daily or placebo in a double-blind fashion. Change in blood pressure and the incidence of hypertension were ascertained. Over a median follow-up time of 7 years, there was no significant difference in the mean change over time in systolic blood pressure (0.22 mm Hg; 95% CI: -0.05 to 0.49 mm Hg) and diastolic blood pressure (0.11 mm Hg; 95% CI: -0.04 to 0.27 mm Hg) between the active and placebo treatment groups. This null result was robust in analyses accounting for nonadherence to study pills and in baseline subgroups of interest, including black subjects and women with hypertension or high levels of blood pressure, with low intakes of calcium and vitamin D or low serum levels of vitamin D. In 17 122 nonhypertensive participants at baseline, the hazard ratio for incident hypertension associated with calcium/vitamin D treatment was 1.01 (95% CI: 0.96 to 1.06.) In postmenopausal women, calcium plus vitamin D3 supplementation did not reduce either blood pressure or the risk of developing hypertension over 7 years of follow-up.

Original languageEnglish (US)
Pages (from-to)847-855
Number of pages9
JournalHypertension
Volume52
Issue number5
DOIs
StatePublished - Nov 2008

Keywords

  • 1
  • 25-Dihydroxyvitaniin D
  • 25-Hydroxyvitamin D
  • Blood pressure
  • Calcium supplementation
  • Clinical trials
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine

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    Margolis, K. L., Ray, R. M., Van Horn, L., Manson, J. A. E., Allison, M. A., Black, H. R., Beresford, S. A. A., Connelly, S. A., David Curb, J., Grimm, R. H., Kotchen, T. A., Kuller, L. H., Wassertheil-Smoller, S., Thomson, C. A., & Torner, J. C. (2008). Effect of calcium and vitamin D supplementation on blood pressure: The women's health initiative randomized trial. Hypertension, 52(5), 847-855. https://doi.org/10.1161/HYPERTENSIONAHA.108.114991