Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats

Charles H. Cohan, Jake T. Neumann, Kunjan R. Dave, Aleksey Alekseyenko, Marc Binkert, Kenneth Stransky, Hung Wen Lin, Carol A Barnes, Clinton B. Wright, Miguel A. Perez-Pinzon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cardiopulmonary arrest is a leading cause of death and disability in the United States that usually occurs in the aged population. Cardiac arrest (CA) induces global ischemia, disrupting global cerebral circulation that results in ischemic brain injury and leads to cognitive impairments in survivors. Ischemia-induced neuronal damage in the hippocampus following CA can result in the impairment of cognitive function including spatial memory. In the present study, we used a model of asphyxial CA (ACA) in nine month old male Fischer 344 rats to investigate cognitive and synaptic deficits following mild global cerebral ischemia. These experiments were performed with the goals of 1) establishing a model of CA in nine month old middle-aged rats; and 2) to test the hypothesis that learning and memory deficits develop following mild global cerebral ischemia in middle-aged rats. To test this hypothesis, spatial memory assays (Barnes circular platform maze and contextual fear conditioning) and field recordings (long-term potentiation and paired-pulse facilitation) were performed. We show that following ACA in nine month old middle-aged rats, there is significant impairment in spatial memory formation, paired-pulse facilitation n dysfunction, and a reduction in the number of non-compromised hippocampal Cornu Ammonis 1 and subiculum neurons. In conclusion, nine month old animals undergoing cardiac arrest have impaired survival, deficits in spatial memory formation, and synaptic dysfunction.

Original languageEnglish (US)
Article numbere0124918
JournalPLoS One
Volume10
Issue number5
DOIs
StatePublished - May 1 2015

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middle-aged adults
cardiac arrest
Heart Arrest
Plasticity
Rats
ischemia
Data storage equipment
rats
Hippocampus
Brain Ischemia
Cerebrovascular Circulation
Ischemia
Long-Term Potentiation
Inbred F344 Rats
Memory Disorders
conditioned behavior
Neurons
hippocampus
Assays
fearfulness

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cohan, C. H., Neumann, J. T., Dave, K. R., Alekseyenko, A., Binkert, M., Stransky, K., ... Perez-Pinzon, M. A. (2015). Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats. PLoS One, 10(5), [e0124918]. https://doi.org/10.1371/journal.pone.0124918

Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats. / Cohan, Charles H.; Neumann, Jake T.; Dave, Kunjan R.; Alekseyenko, Aleksey; Binkert, Marc; Stransky, Kenneth; Lin, Hung Wen; Barnes, Carol A; Wright, Clinton B.; Perez-Pinzon, Miguel A.

In: PLoS One, Vol. 10, No. 5, e0124918, 01.05.2015.

Research output: Contribution to journalArticle

Cohan, CH, Neumann, JT, Dave, KR, Alekseyenko, A, Binkert, M, Stransky, K, Lin, HW, Barnes, CA, Wright, CB & Perez-Pinzon, MA 2015, 'Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats', PLoS One, vol. 10, no. 5, e0124918. https://doi.org/10.1371/journal.pone.0124918
Cohan CH, Neumann JT, Dave KR, Alekseyenko A, Binkert M, Stransky K et al. Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats. PLoS One. 2015 May 1;10(5). e0124918. https://doi.org/10.1371/journal.pone.0124918
Cohan, Charles H. ; Neumann, Jake T. ; Dave, Kunjan R. ; Alekseyenko, Aleksey ; Binkert, Marc ; Stransky, Kenneth ; Lin, Hung Wen ; Barnes, Carol A ; Wright, Clinton B. ; Perez-Pinzon, Miguel A. / Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats. In: PLoS One. 2015 ; Vol. 10, No. 5.
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