Abstract
Lipid peroxidative activity in rats made diabetic with streptozocin and rats made acutely hyperglycemic by intraperitoneal dextrose administration was determined by measurement of exhaled ethane during exposure in vivo to ethane-free air (EFA). Diabetic rats demonstrated increased ethane in the expired breath while breathing EFA (5.82 ± 0.56 pmol / min /100 g) compared with control rats (4.02 ± 0.23 pmol/ min/ 100 g). Insulin treatment of diabetic rats attenuated the ethane produced (4.88 ± 0.23 pmol/ min /100 g). Acute hyperglycemia increased exhaled ethane to levels higher than those seen in diabetic rats (9.87 ± 0.98 pmol/ min/ 100 g). Saline injected intraperitoneally to control rats produced ethane levels similar to those of untreated nondiabetic controls (4.11 ± 0.52 pmol/ min / 100 g). Chronic uncontrolled hyperglycemia and acute hyperglycemia are associated with increased in vivo ethane production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1442-1445 |
| Number of pages | 4 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 43 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
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Effect of diabetes, insulin, and glucose load on lipid peroxidation in the rat. / Habib, Michael P; Dickerson, Frank D.; Mooradian, Arshag D.
In: Metabolism: Clinical and Experimental, Vol. 43, No. 11, 1994, p. 1442-1445.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of diabetes, insulin, and glucose load on lipid peroxidation in the rat
AU - Habib, Michael P
AU - Dickerson, Frank D.
AU - Mooradian, Arshag D.
PY - 1994
Y1 - 1994
N2 - Lipid peroxidative activity in rats made diabetic with streptozocin and rats made acutely hyperglycemic by intraperitoneal dextrose administration was determined by measurement of exhaled ethane during exposure in vivo to ethane-free air (EFA). Diabetic rats demonstrated increased ethane in the expired breath while breathing EFA (5.82 ± 0.56 pmol / min /100 g) compared with control rats (4.02 ± 0.23 pmol/ min/ 100 g). Insulin treatment of diabetic rats attenuated the ethane produced (4.88 ± 0.23 pmol/ min /100 g). Acute hyperglycemia increased exhaled ethane to levels higher than those seen in diabetic rats (9.87 ± 0.98 pmol/ min/ 100 g). Saline injected intraperitoneally to control rats produced ethane levels similar to those of untreated nondiabetic controls (4.11 ± 0.52 pmol/ min / 100 g). Chronic uncontrolled hyperglycemia and acute hyperglycemia are associated with increased in vivo ethane production.
AB - Lipid peroxidative activity in rats made diabetic with streptozocin and rats made acutely hyperglycemic by intraperitoneal dextrose administration was determined by measurement of exhaled ethane during exposure in vivo to ethane-free air (EFA). Diabetic rats demonstrated increased ethane in the expired breath while breathing EFA (5.82 ± 0.56 pmol / min /100 g) compared with control rats (4.02 ± 0.23 pmol/ min/ 100 g). Insulin treatment of diabetic rats attenuated the ethane produced (4.88 ± 0.23 pmol/ min /100 g). Acute hyperglycemia increased exhaled ethane to levels higher than those seen in diabetic rats (9.87 ± 0.98 pmol/ min/ 100 g). Saline injected intraperitoneally to control rats produced ethane levels similar to those of untreated nondiabetic controls (4.11 ± 0.52 pmol/ min / 100 g). Chronic uncontrolled hyperglycemia and acute hyperglycemia are associated with increased in vivo ethane production.
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U2 - 10.1016/0026-0495(94)90042-6
DO - 10.1016/0026-0495(94)90042-6
M3 - Article
VL - 43
SP - 1442
EP - 1445
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 11
ER -