Effect of diet on preference and intake of sucrose in obese prone and resistant rats

Frank A. Duca, Timothy D. Swartz, Mihai Covasa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Increased orosensory stimulation from palatable diets and decreased feedback from gut signals have been proposed as contributing factors to obesity development. Whether altered taste functions associated with obesity are common traits or acquired deficits to environmental factors, such as a high-energy (HE)-diet, however, is not clear. To address this, we examined preference and sensitivity of increasing concentrations of sucrose solutions in rats prone (OP) and resistant (OR) to obesity during chow and HE feeding and measured lingual gene expression of the sweet taste receptor T1R3. When chow-fed, OP rats exhibited reduced preference and acceptance of dilute sucrose solutions, sham-fed less sucrose compared to OR rats, and had reduced lingual T1R3 gene expression. HE-feeding abrogated differences in sucrose preference and intake and lingual T1R3 expression between phenotypes. Despite similar sucrose intakes however, OP rats consumed significantly more total calories during 48-h two-bottle testing compared to OR rats. The results demonstrate that OP rats have an innate deficit for sweet taste detection, as illustrated by a reduction in sensitivity to sweets and reduced T1R3 gene expression; however their hyperphagia and subsequent obesity during HE-feeding is most likely not due to altered consumption of sweets.

Original languageEnglish (US)
Article numbere111232
JournalPloS one
Volume9
Issue number10
DOIs
StatePublished - Oct 20 2014
Externally publishedYes

Fingerprint

Nutrition
Sucrose
Rats
sucrose
Diet
rats
obesity
Obesity
tongue
Tongue
Gene expression
diet
Gene Expression
gene expression
energy
Dysgeusia
Hyperphagia
high energy diet
overeating
Bottles

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Effect of diet on preference and intake of sucrose in obese prone and resistant rats. / Duca, Frank A.; Swartz, Timothy D.; Covasa, Mihai.

In: PloS one, Vol. 9, No. 10, e111232, 20.10.2014.

Research output: Contribution to journalArticle

Duca, Frank A. ; Swartz, Timothy D. ; Covasa, Mihai. / Effect of diet on preference and intake of sucrose in obese prone and resistant rats. In: PloS one. 2014 ; Vol. 9, No. 10.
@article{5121d4043aaf4d9cbe0c103e9b367230,
title = "Effect of diet on preference and intake of sucrose in obese prone and resistant rats",
abstract = "Increased orosensory stimulation from palatable diets and decreased feedback from gut signals have been proposed as contributing factors to obesity development. Whether altered taste functions associated with obesity are common traits or acquired deficits to environmental factors, such as a high-energy (HE)-diet, however, is not clear. To address this, we examined preference and sensitivity of increasing concentrations of sucrose solutions in rats prone (OP) and resistant (OR) to obesity during chow and HE feeding and measured lingual gene expression of the sweet taste receptor T1R3. When chow-fed, OP rats exhibited reduced preference and acceptance of dilute sucrose solutions, sham-fed less sucrose compared to OR rats, and had reduced lingual T1R3 gene expression. HE-feeding abrogated differences in sucrose preference and intake and lingual T1R3 expression between phenotypes. Despite similar sucrose intakes however, OP rats consumed significantly more total calories during 48-h two-bottle testing compared to OR rats. The results demonstrate that OP rats have an innate deficit for sweet taste detection, as illustrated by a reduction in sensitivity to sweets and reduced T1R3 gene expression; however their hyperphagia and subsequent obesity during HE-feeding is most likely not due to altered consumption of sweets.",
author = "Duca, {Frank A.} and Swartz, {Timothy D.} and Mihai Covasa",
year = "2014",
month = "10",
day = "20",
doi = "10.1371/journal.pone.0111232",
language = "English (US)",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

TY - JOUR

T1 - Effect of diet on preference and intake of sucrose in obese prone and resistant rats

AU - Duca, Frank A.

AU - Swartz, Timothy D.

AU - Covasa, Mihai

PY - 2014/10/20

Y1 - 2014/10/20

N2 - Increased orosensory stimulation from palatable diets and decreased feedback from gut signals have been proposed as contributing factors to obesity development. Whether altered taste functions associated with obesity are common traits or acquired deficits to environmental factors, such as a high-energy (HE)-diet, however, is not clear. To address this, we examined preference and sensitivity of increasing concentrations of sucrose solutions in rats prone (OP) and resistant (OR) to obesity during chow and HE feeding and measured lingual gene expression of the sweet taste receptor T1R3. When chow-fed, OP rats exhibited reduced preference and acceptance of dilute sucrose solutions, sham-fed less sucrose compared to OR rats, and had reduced lingual T1R3 gene expression. HE-feeding abrogated differences in sucrose preference and intake and lingual T1R3 expression between phenotypes. Despite similar sucrose intakes however, OP rats consumed significantly more total calories during 48-h two-bottle testing compared to OR rats. The results demonstrate that OP rats have an innate deficit for sweet taste detection, as illustrated by a reduction in sensitivity to sweets and reduced T1R3 gene expression; however their hyperphagia and subsequent obesity during HE-feeding is most likely not due to altered consumption of sweets.

AB - Increased orosensory stimulation from palatable diets and decreased feedback from gut signals have been proposed as contributing factors to obesity development. Whether altered taste functions associated with obesity are common traits or acquired deficits to environmental factors, such as a high-energy (HE)-diet, however, is not clear. To address this, we examined preference and sensitivity of increasing concentrations of sucrose solutions in rats prone (OP) and resistant (OR) to obesity during chow and HE feeding and measured lingual gene expression of the sweet taste receptor T1R3. When chow-fed, OP rats exhibited reduced preference and acceptance of dilute sucrose solutions, sham-fed less sucrose compared to OR rats, and had reduced lingual T1R3 gene expression. HE-feeding abrogated differences in sucrose preference and intake and lingual T1R3 expression between phenotypes. Despite similar sucrose intakes however, OP rats consumed significantly more total calories during 48-h two-bottle testing compared to OR rats. The results demonstrate that OP rats have an innate deficit for sweet taste detection, as illustrated by a reduction in sensitivity to sweets and reduced T1R3 gene expression; however their hyperphagia and subsequent obesity during HE-feeding is most likely not due to altered consumption of sweets.

UR - http://www.scopus.com/inward/record.url?scp=84908192072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908192072&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0111232

DO - 10.1371/journal.pone.0111232

M3 - Article

C2 - 25329959

AN - SCOPUS:84908192072

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e111232

ER -