Effect of early immunization on antibody response to reimmunization with measles vaccine as demonstrated by enzyme-linked immunosorbent assay (ELISA)

M. D. Murphy, P. A. Brunell, A. W. Lievens, Ziad M Shehab

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A measles epidemic in San Antonio, Texas provided a population of children who were immunized at ≤10 months of age and reimmunized at ≥15 months of age. Of these children, 302 were evaluated for measles antibody by the sensitive enzyme-linked immunosorbent assay (ELISA), and their responses were compared with those of 300 children who had been immunized at the customary time (≥15 months) with a single immunization. There were only five seronegative findings in each group. The children immunized at the customary time did have significantly higher (P < .001) antibody titers than the children immunized at ≤10 months and reimmunized at ≥15 months. These results indicate that early immunization followed by reimmunization may be indicated when young infants are at significant risk of measles exposure. This approach should not create an increased number of serologically nonresponsive children when reimmunized at ≥15 months.

Original languageEnglish (US)
Pages (from-to)90-93
Number of pages4
JournalPediatrics
Volume74
Issue number1
StatePublished - 1984
Externally publishedYes

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Measles Vaccine
Antibody Formation
Immunization
Enzyme-Linked Immunosorbent Assay
Measles
Antibodies
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of early immunization on antibody response to reimmunization with measles vaccine as demonstrated by enzyme-linked immunosorbent assay (ELISA). / Murphy, M. D.; Brunell, P. A.; Lievens, A. W.; Shehab, Ziad M.

In: Pediatrics, Vol. 74, No. 1, 1984, p. 90-93.

Research output: Contribution to journalArticle

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