Effect of epidural analgesia on postoperative complications following pancreaticoduodenectomy

Albert Amini, Asad E Patanwala, Felipe B. Maegawa, Grant H. Skrepnek, Tun Jie, Rainer W G Gruessner, Evan S. Ong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The purpose of this study was to evaluate the effect of epidural analgesia use on postoperative complications in patients undergoing pancreaticoduodenectomy. Methods: This retrospective cohort study used the 2009 Nationwide Inpatient Sample from the Agency for Healthcare Research and Quality. Patients who underwent pancreaticoduodenectomy were grouped on the basis of whether they received epidural analgesia. The effect of epidural use on the composite end point of major complications including death was investigated using a generalized linear model. Results: Overall, 8,610 cases of pancreaticoduodenectomy occurred within the United States in 2009, and 11.0% of these patients received epidural analgesia. After controlling for various potential confounders, results of the multivariate regression indicated that epidural analgesia use was associated with lower odds of composite complications including death (odds ratio,.61; 95% confidence interval,.37-.99; P =.044). Conclusions: In patients who underwent pancreaticoduodenectomy, epidural analgesia was associated with significantly lower postoperative composite complications.

Original languageEnglish (US)
Pages (from-to)1000-1006
Number of pages7
JournalAmerican Journal of Surgery
Volume204
Issue number6
DOIs
StatePublished - Dec 2012

Fingerprint

Pancreaticoduodenectomy
Epidural Analgesia
Health Services Research
Inpatients
Linear Models
Cohort Studies
Retrospective Studies
Odds Ratio
Confidence Intervals

Keywords

  • Complications
  • Epidural analgesia
  • Pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of epidural analgesia on postoperative complications following pancreaticoduodenectomy. / Amini, Albert; Patanwala, Asad E; Maegawa, Felipe B.; Skrepnek, Grant H.; Jie, Tun; Gruessner, Rainer W G; Ong, Evan S.

In: American Journal of Surgery, Vol. 204, No. 6, 12.2012, p. 1000-1006.

Research output: Contribution to journalArticle

Amini, Albert ; Patanwala, Asad E ; Maegawa, Felipe B. ; Skrepnek, Grant H. ; Jie, Tun ; Gruessner, Rainer W G ; Ong, Evan S. / Effect of epidural analgesia on postoperative complications following pancreaticoduodenectomy. In: American Journal of Surgery. 2012 ; Vol. 204, No. 6. pp. 1000-1006.
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