Effect of food intake on the relative bioavailability of moclobemide (Ro 11-1163).

M. P. Schoerlin, M. Mayersohn, B. Hoevels, H. Eggers, M. Dellenbach, J. P. Pfefen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Twelve healthy adult volunteers received a single 100-mg tablet of moclobemide in an open-label crossover study designed to determine the influence of food on moclobemide absorption. Moclobemide was administered 30 min after a standard breakfast as well as under fasting conditions. Moclobemide absorption was rapid in the absence of food. Bioavailability parameters obtained when drug was taken 30 min after the meal suggested that the rate of absorption was slightly decreased in the presence of food (mean Tmax 0.71 h vs. 1.14 h), while the extent of absorption of moclobemide given with food was unaltered. The decreased absorption rate in the presence of food is not expected to be of clinical significance.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalJournal of neural transmission. Supplementum
Volume26
StatePublished - 1988

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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