Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid

J. A. Bianco, D. R. Elmaleh, J. A. Leppo, M. A. King, A. Moring, E. Livni, E. Espinoza, Joseph S Alpert, H. W. Strauss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated the one-way. AV extraction of 14-iodophenyl-tetradecanoic acid (BMTDA) in the canine heart under fasting conditions and during infusion of glucose plus insulin in eight anesthetized greyhound dogs. Myocardial extraction measurements were made with dual tracer approach, using Tc-99m albumin as reference tracer. Prior to, and during, infusion of 10% glucose and 25 units of regular insulin, heart rate, blood pressure, plasma glucose, insulin and free fatty acid levels were measured. Myocardial blood flow was determined using Sn-113 and Ru-103 radioactive microspheres. The mean extraction fraction of BMTDA was 0.38±SEM 0.06 at baseline and increased to 0.44±0.06 during hyperglycemia plus insulin (P<0.025). Plasma glucose and insulin were higher during the infusion (P<0.01) while plasma free fatty acids significantly declined (P<0.01). There were no changes in hemodynamics or myocardial blood flow during the infusion. We conclude that glucose and insulin infusion result in increased firstpass extraction fraction of radioiodinated BMTDA unaccompanied by changes in coronary flow or hemodynamics, implying an insulin-mediated augmented transport of BMTDA.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalEuropean Journal of Nuclear Medicine
Volume12
Issue number3
DOIs
StatePublished - Jul 1986
Externally publishedYes

Fingerprint

Fatty Acids
Insulin
Glucose
Nonesterified Fatty Acids
Hemodynamics
Technetium Tc 99m Aggregated Albumin
Myristic Acid
Microspheres
Hyperglycemia
Canidae
Fasting
Heart Rate
Dogs
Blood Pressure
14-(iodophenyl)-3-methyltetradecanoic acid

Keywords

  • Glucose and insulin infusion
  • Myocardialextraction
  • Radioiodinated methyl-substituted fatty acid

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Bianco, J. A., Elmaleh, D. R., Leppo, J. A., King, M. A., Moring, A., Livni, E., ... Strauss, H. W. (1986). Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid. European Journal of Nuclear Medicine, 12(3), 120-124. https://doi.org/10.1007/BF00276703

Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid. / Bianco, J. A.; Elmaleh, D. R.; Leppo, J. A.; King, M. A.; Moring, A.; Livni, E.; Espinoza, E.; Alpert, Joseph S; Strauss, H. W.

In: European Journal of Nuclear Medicine, Vol. 12, No. 3, 07.1986, p. 120-124.

Research output: Contribution to journalArticle

Bianco, JA, Elmaleh, DR, Leppo, JA, King, MA, Moring, A, Livni, E, Espinoza, E, Alpert, JS & Strauss, HW 1986, 'Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid', European Journal of Nuclear Medicine, vol. 12, no. 3, pp. 120-124. https://doi.org/10.1007/BF00276703
Bianco, J. A. ; Elmaleh, D. R. ; Leppo, J. A. ; King, M. A. ; Moring, A. ; Livni, E. ; Espinoza, E. ; Alpert, Joseph S ; Strauss, H. W. / Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid. In: European Journal of Nuclear Medicine. 1986 ; Vol. 12, No. 3. pp. 120-124.
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