Effect of Hyperbaric oxygen therapy on tense repair of the peripheral nerves

Bengusu Oroglu, Tolga Turker, Samil Aktas, Vakur Olgac, Mehmet Alp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: After a peripheral nerve cut, tense repair of a nerve compromises circulation of the nerve at the injury site, making the site hypoxic. Hyperbaric oxygen might increase tissue oxygenation and therefore diminish the effects of injury. We investigated whether hyperbaric oxygen treatment affects peripheral nerve healing when repaired nerves are under tension. Methods: Sixteen young female albino Wistar rats were used. Sciatic nerves of the animals were cut and a 3mm part of each nerve was excised. The animals were distributed into two groups: 1) The HBO2 group (n=8), which received surgical repair and HBO2 therapy; and 2) The Control group (n=8), which received only surgical repair. Walking track analysis was performed five times, on Days 12, 15, 18, 20 and 22 after surgery. The healing of sciatic nerves was evaluated by histopathological study and electrophysiological study. Pillai's Trace test and Mann-Whitney U-test were used for statistical analysis. Results: Walking track analysis: Sciatic function index (SFI) scores of HBO2 group were significantly higher than SFI scores of Control group (p:0.026). Electrophysiological study: A statistical difference was not found between groups. Histopathological study: Counts of HBO2 group axons were significantly greater than in the control group (p: 0.008). Conclusions: In clinical practice, tension after nerve repair frequently occurs. However, neither grafting nor other current surgical methods are functionally perfect. Since primary end-to-end repair is known to be the best repair when possible, we think HBO2 allows for the use of primary repair even when nerve tension is foreseen.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalUndersea and Hyperbaric Medicine
Volume38
Issue number5
StatePublished - Sep 2011
Externally publishedYes

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Hyperbaric Oxygenation
Peripheral Nerves
Sciatic Nerve
Control Groups
Walking
Oxygen
Wounds and Injuries
Nonparametric Statistics
Axons
Wistar Rats
Therapeutics

ASJC Scopus subject areas

  • Physiology (medical)
  • Pulmonary and Respiratory Medicine

Cite this

Effect of Hyperbaric oxygen therapy on tense repair of the peripheral nerves. / Oroglu, Bengusu; Turker, Tolga; Aktas, Samil; Olgac, Vakur; Alp, Mehmet.

In: Undersea and Hyperbaric Medicine, Vol. 38, No. 5, 09.2011, p. 367-373.

Research output: Contribution to journalArticle

Oroglu, Bengusu ; Turker, Tolga ; Aktas, Samil ; Olgac, Vakur ; Alp, Mehmet. / Effect of Hyperbaric oxygen therapy on tense repair of the peripheral nerves. In: Undersea and Hyperbaric Medicine. 2011 ; Vol. 38, No. 5. pp. 367-373.
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